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Title: Expression and function of gastrin-releasing peptide (GRP) in normal and cancerous urological tissues.
Authors: Ischia, Joseph J;Patel, Oneel;Bolton, Damien M;Shulkes, Arthur;Baldwin, Graham S
Affiliation: Department of Surgery, Austin Health, Melbourne, VIC, Australia; Department of Urology, University of Melbourne, Austin Health, Melbourne, VIC, Australia.
Issue Date: 1-Mar-2014
Citation: Bju International; 113 Suppl 2(): 40-7
Abstract: Gastrin-releasing peptide (GRP) acts as an important regulatory peptide in several normal physiological processes and as a growth factor in certain cancers. In this review we provide a comprehensive overview of the current state of knowledge of GRP in urological tissues under both normal and cancerous conditions. GRP and its receptor, GRP-R, are expressed in the normal kidney and renal cancers. GRP can stimulate the growth of renal cancer cells. GRP and GRP-R are expressed in prostate cancer and GRP can stimulate the growth of prostate cancer cell lines. Importantly, GRP is a key neuroendocrine peptide, which may be involved in the progression of advanced prostate cancer and in the neuroendocrine differentiation of prostate cancer. Recent animal studies have shown that GRP and GRP-R are an integral part of male sexual function and play a crucial role in spinal control of erections and ejaculation.
Internal ID Number: 24894852
DOI: 10.1111/bju.12594
Type: Journal Article
Subjects: bombesin
gastrin-releasing peptide (GRP)
prostate cancer
renal cancer
sexual function
Carcinoma, Renal Cell.metabolism.physiopathology
Cell Line, Tumor
Disease Progression
Gastrin-Releasing Peptide.genetics.metabolism
Gene Expression Regulation, Neoplastic
Kidney Neoplasms.metabolism.physiopathology
Prostatic Neoplasms.metabolism.physiopathology
Receptors, Bombesin.genetics.metabolism
Synaptic Transmission
Appears in Collections:Journal articles

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