Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/12241
Title: Sleep disruption in tetraplegia: a randomised, double-blind, placebo-controlled crossover trial of 3 mg melatonin.
Authors: Spong, J;Kennedy, G A;Tseng, J;Brown, Douglas J;Armstrong, S M;Berlowitz, David J
Affiliation: Institute for Breathing and Sleep, Austin Hospital, Melbourne, Victoria, Australia.
1] Institute for Breathing and Sleep, Austin Hospital, Melbourne, Victoria, Australia [2] Psychology Department, College of Arts, Victoria University, Melbourne, Victoria, Australia [3] The Bronowski Institute of Behavioural Neuroscience, Kyneton, Victoria, Australia.
Department of Emergency Medicine, The Northern Hospital, Melbourne, Victoria, Australia.
Spinal Research Institute, Austin Health, Melbourne, Victoria, Australia.
1] The Bronowski Institute of Behavioural Neuroscience, Kyneton, Victoria, Australia [2] Epworth Sleep Centre, Melbourne, Victoria, Australia.
1] Institute for Breathing and Sleep, Austin Hospital, Melbourne, Victoria, Australia [2] Spinal Research Institute, Austin Health, Melbourne, Victoria, Australia [3] Department of Medicine, Austin Health and Northern Health, University of Melbourne, Melbourne, Victoria, Australia.
Issue Date: 3-Jun-2014
Citation: Spinal Cord 2014; 52(8): 629-34
Abstract: Randomised, double-blind, placebo-controlled crossover trial of melatonin supplementation to people with complete tetraplegia.To investigate the effect that 3 mg melatonin supplementation has on objective and subjective sleep, quality of life and mood of people living with complete tetraplegia.Austin Hospital Sleep Laboratory and participants' homes, Melbourne, Victoria, Australia.Two week run-in followed by 3 week nightly administration of 3 mg melatonin or placebo, 2-week washout and further 3 week administration of the opposite treatment. Four testing sessions were conducted; the last nights of the run-in, treatment and washout periods. Testing sessions involved recording full polysomnography, completing a questionnaire battery and collecting urine and blood samples. The questionnaires assessed mood, sleep symptoms and health-related quality of life, and the urine and plasma samples assayed 6-sulphatoxymelatonin (aMT6s) and melatonin levels, respectively. A sleep diary was completed throughout the study.Eight participants (mean (s.d.): age 49.5 years (16), postinjury 16.9 years (7.1)) were recruited in which seven concluded the protocol. Endogenous-circulating melatonin was significantly higher (P < or = 0.01) following melatonin (urine: 152.94 μg h(-1) (74.51), plasma: 43,554.57 pM (33,527.11)) than placebo (urine: 0.86 μg h(-1) (0.40), plasma: 152.06 pM (190.55)). Subjective sleep improved significantly following melatonin specifically for duration of sleep per night and psychological wellbeing. Objective sleep showed a significant increase in light sleep with melatonin, with all other sleep parameters being unchanged.These results suggest that increasing melatonin in people with complete tetraplegia is beneficial, especially for subjective sleep. Investigation of the pharmacokinetics of melatonin metabolism in this population is warranted.This project is proudly supported by the Transport Accident Commission.
Internal ID Number: 24891007
URI: http://ahro.austin.org.au/austinjspui/handle/1/12241
DOI: 10.1038/sc.2014.84
URL: http://www.ncbi.nlm.nih.gov/pubmed/24891007
Type: Journal Article
Subjects: Adult
Affect.drug effects
Aged
Antioxidants.metabolism.therapeutic use
Cross-Over Studies
Double-Blind Method
Female
Humans
Male
Melatonin.analogs & derivatives.blood.therapeutic use.urine
Middle Aged
Polysomnography
Quadriplegia.complications.drug therapy.psychology
Quality of Life
Questionnaires
Sleep Disorders.blood.drug therapy.etiology.urine
Appears in Collections:Journal articles

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