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Title: One gene, many neuropsychiatric disorders: lessons from Mendelian diseases.
Authors: Zhu, Xiaolin;Need, Anna C;Petrovski, Slavé;Goldstein, David B
Affiliation: [2] Division of Brain Sciences, Department of Medicine, Imperial College London, London, UK
Center for Human Genome Variation, Duke University School of Medicine, Durham, North Carolina, USA
1] Center for Human Genome Variation, Duke University School of Medicine, Durham, North Carolina, USA
[2] Department of Medicine, The University of Melbourne, Austin Health and Royal Melbourne Hospital, Melbourne, Victoria, Australia
Issue Date: 27-May-2014
Citation: Nature Neuroscience 2014; 17(6): 773-81
Abstract: Recent human genetic studies have consistently shown that mutations in the same gene or same genomic region can increase the risk of a broad range of complex neuropsychiatric disorders. Despite the steadily increasing number of examples of such nonspecific effects on risk, the underlying biological causes remain mysterious. Here we investigate the phenomenon of such nonspecific risk by identifying Mendelian disease genes that are associated with multiple diseases and explore what is known about the underlying mechanisms in these more 'simple' examples. Our analyses make clear that there are a variety of mechanisms at work, emphasizing how challenging it will be to elucidate the causes of nonspecific risk in complex disease. Ultimately, we conclude that functional approaches will be critical for explaining the causes of nonspecific risk factors discovered by human genetic studies of neuropsychiatric disorders.
Internal ID Number: 24866043
DOI: 10.1038/nn.3713
Type: Journal Article
Subjects: Animals
Genetic Predisposition to Disease.genetics
Mendelian Randomization Analysis.methods.trends
Mental Disorders.diagnosis.genetics
Appears in Collections:Journal articles

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