Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/12215
Title: Comparative strength and dendritic organization of thalamocortical and corticocortical synapses onto excitatory layer 4 neurons.
Authors: Schoonover, Carl E;Tapia, Juan-Carlos;Schilling, Verena C;Wimmer, Verena;Blazeski, Richard;Zhang, Wanying;Mason, Carol A;Bruno, Randy M
Affiliation: Department of Neuroscience and Kavli Institute for Brain Science, Columbia University, New York, New York 10032.
Max Planck Institute for Medical Research, D-69120 Heidelberg, Germany.
The Florey Institute of Neuroscience and Mental Health, Parkville VIC 3010, Australia, and.
Department of Pathology, Columbia University, New York, New York 10032.
Department of Neuroscience and Kavli Institute for Brain Science, Columbia University, New York, New York 10032, Department of Pathology, Columbia University, New York, New York 10032.
Department of Neuroscience and Kavli Institute for Brain Science, Columbia University, New York, New York 10032, randybruno@columbia.edu.
Issue Date: 14-May-2014
Citation: The Journal of Neuroscience : the Official Journal of the Society For Neuroscience; 34(20): 6746-58
Abstract: Thalamus is a potent driver of cortical activity even though cortical synapses onto excitatory layer 4 neurons outnumber thalamic synapses 10 to 1. Previous in vitro studies have proposed that thalamocortical (TC) synapses are stronger than corticocortical (CC) synapses. Here, we investigated possible anatomical and physiological differences between these inputs in the rat in vivo. We developed a high-throughput light microscopy method, validated by electron microscopy, to completely map the locations of synapses across an entire dendritic tree. This demonstrated that TC synapses are slightly more proximal to the soma than CC synapses, but detailed compartmental modeling predicted that dendritic filtering does not appreciably favor one synaptic class over another. Measurements of synaptic strength in intact animals confirmed that both TC and CC synapses are weak and approximately equivalent. We conclude that thalamic effectiveness does not rely on enhanced TC strength, but rather on coincident activation of converging inputs.
Internal ID Number: 24828630
URI: http://ahro.austin.org.au/austinjspui/handle/1/12215
DOI: 10.1523/JNEUROSCI.0305-14.2014
URL: http://www.ncbi.nlm.nih.gov/pubmed/24828630
Type: Journal Article
Subjects: compartmental
confocal
dendrite
in vivo
optogenetics
synapse
Action Potentials.physiology
Animals
Cerebral Cortex.physiology
Dendrites.physiology
Dendritic Spines.physiology
Models, Neurological
Neural Pathways.physiology
Neurons.physiology
Rats
Rats, Wistar
Synapses.physiology
Synaptic Transmission.physiology
Thalamus.physiology
Appears in Collections:Journal articles

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