Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/12157
Title: Systemic VEGF-A neutralization ameliorates diet-induced metabolic dysfunction.
Authors: Wu, Lindsay E;Meoli, Christopher C;Mangiafico, Salvatore P;Fazakerley, Daniel J;Cogger, Victoria C;Mohamad, Mashani;Pant, Himani;Kang, Myung-Jin;Powter, Elizabeth;Burchfield, James G;Xirouchaki, Chrysovalantou E;Mikolaizak, A Stefanie;Stöckli, Jacqueline;Kolumam, Ganesh;van Bruggen, Nicholas;Gamble, Jennifer R;Le Couteur, David G;Cooney, Gregory J;Andrikopoulos, Sofianos;James, David E
Affiliation: Diabetes and Obesity Program, Garvan Institute of Medical Research, Darlinghurst, New South Wales, AustraliaLaboratory for Ageing Research, School of Medical Sciences, UNSW Australia, New South Wales, Australia.
Diabetes and Obesity Program, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia.
Centre for Education and Research on Ageing and ANZAC Medical Research Institute, University of Sydney and Concord Hospital, Concord, New South Wales, AustraliaFaculty of Pharmacy, Universiti Teknologi MARA, Bandar Puncak Alam, Selangor, Malaysia.
Laboratory for Ageing Research, School of Medical Sciences, UNSW Australia, New South Wales, Australia.
Falls and Balance Research Group, Neuroscience Research Australia, Sydney, Australia.
Department of Biomedical Imaging, Genentech Inc., San Francisco, CA.
Centre for the Endothelium, Vascular Biology Program, Centenary Institute, and The University of Sydney, Sydney, Australia.
Centre for Education and Research on Ageing and ANZAC Medical Research Institute, University of Sydney and Concord Hospital, Concord, New South Wales, Australia.
Department of Medicine (Austin Health), The University of Melbourne, Heidelberg, Victoria, Australia.
Diabetes and Obesity Program, Garvan Institute of Medical Research, Darlinghurst, New South Wales, AustraliaCharles Perkins Centre, School of Molecular Bioscience, The University of Sydney, Sydney, Australia david.james@sydney.edu.au.
Issue Date: 2-Apr-2014
Citation: Diabetes 2014; 63(8): 2656-67
Abstract: The vascular endothelial growth factor (VEGF) family of cytokines are important regulators of angiogenesis that have emerged as important targets for the treatment of obesity. While serum VEGF levels rise during obesity, recent studies using genetic models provide conflicting evidence as to whether VEGF prevents or accelerates metabolic dysfunction during obesity. In the current study, we sought to identify the effects of VEGF-A neutralization on parameters of glucose metabolism and insulin action in a dietary mouse model of obesity. Within only 72 h of administration of the VEGF-A-neutralizing monoclonal antibody B.20-4.1, we observed almost complete reversal of high-fat diet-induced insulin resistance principally due to improved insulin sensitivity in the liver and in adipose tissue. These effects were independent of changes in whole-body adiposity or insulin signaling. These findings show an important and unexpected role for VEGF in liver insulin resistance, opening up a potentially novel therapeutic avenue for obesity-related metabolic disease.
Internal ID Number: 24696450
URI: http://ahro.austin.org.au/austinjspui/handle/1/12157
DOI: 10.2337/db13-1665
URL: http://www.ncbi.nlm.nih.gov/pubmed/24696450
Type: Journal Article
Subjects: Adiposity.physiology
Animal Feed.analysis
Animals
Antibodies.pharmacology
Dietary Fats.administration & dosage.adverse effects
Glucose.metabolism
Homeostasis.physiology
Immunoglobulin G.pharmacology
Insulin.metabolism
Insulin Resistance
Liver.metabolism
Male
Mice
Obesity
Signal Transduction
Vascular Endothelial Growth Factor A.genetics.metabolism
Appears in Collections:Journal articles

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