Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/12155
Title: MRI scans significantly change target coverage decisions in radical radiotherapy for prostate cancer.
Authors: Chang, Joe H;Lim Joon, Daryl;Nguyen, Brandon T;Hiew, Chee-Yan;Esler, Stephen;Angus, David;Chao, Michael;Wada, Morikatsu;Quong, George;Khoo, Vincent
Affiliation: Division of Radiation Oncology and Cancer Imaging, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
Radiation Oncology Centre, Austin Health, Heidelberg, Victoria, Australiatoria, Australia
University of Melbourne, Melbourne, Victoria, Australia
Issue Date: 29-Aug-2013
Citation: Journal of Medical Imaging and Radiation Oncology 2013; 58(2): 237-43
Abstract: Conventional clinical staging for prostate cancer has many limitations. This study evaluates the impact of adding MRI scans to conventional clinical staging for guiding decisions about radiotherapy target coverage.This was a retrospective review of 115 patients who were treated between February 2002 and September 2005 with radical radiotherapy for prostate cancer. All patients had MRI scans approximately 2 weeks before the initiation of radiotherapy. The T stage was assessed by both conventional clinical methods (cT-staging) as well as by MRI (mT-staging). The radiotherapy target volumes were determined first based on cT-staging and then taking the additional mT staging into account. The number of times extracapsular extension or seminal vesicle invasion was incorporated into target volumes was quantified based on both cT-staging and the additional mT-staging.Extracapsular extension was incorporated into target volumes significantly more often with the addition of mT-staging (46 patients (40%) ) compared with cT-staging alone (37 patients (32%) ) (P = 0.002). Seminal vesicle invasion was incorporated into target volumes significantly more often with the addition of mT-staging (21 patients (18%) ) compared with cT-staging alone (three patients (3%) ) (P < 0.001). A total of 23 patients (20%) had changes to their target coverage based on the mT-staging.MRI scans can significantly change decisions about target coverage in radical radiotherapy for prostate cancer.
Internal ID Number: 24690247
URI: http://ahro.austin.org.au/austinjspui/handle/1/12155
DOI: 10.1111/1754-9485.12107
URL: http://www.ncbi.nlm.nih.gov/pubmed/24690247
Type: Journal Article
Subjects: magnetic resonance imaging
prostate cancer
radiotherapy
target volume delineation
Aged
Aged, 80 and over
Algorithms
Humans
Image Interpretation, Computer-Assisted.methods
Male
Middle Aged
Neoplasm Staging
Prostatic Neoplasms.pathology.radiotherapy
Radiotherapy Dosage
Radiotherapy, Image-Guided.methods
Reproducibility of Results
Retrospective Studies
Sensitivity and Specificity
Treatment Outcome
Appears in Collections:Journal articles

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