Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/12143
Title: Immune monitoring post liver transplant.
Authors: Sood, Siddharth;Testro, Adam G
Affiliation: Siddharth Sood, Adam G Testro, Liver Transplant Unit Victoria, Level 8 HSB, Austin Health, University of Melbourne, Melbourne, Victoria 3084, Australia
Issue Date: 24-Mar-2014
Citation: World Journal of Transplantation; 4(1): 30-9
Abstract: Many of the causes of short and late morbidity following liver transplantation are associated with immunosuppression or immunosuppressive medications. Current care often involves close monitoring of liver biochemistry as well as therapeutic drug levels. However, the postoperative course following liver transplantation can often be associated with significant complications including infection and rejection, suggesting an inadequacy in current immune function monitoring. Many assays have been tested in the research setting to identify possible biomarkers that may be used to predict clinical events such as acute cellular rejection, and therefore allow modification of a patient's immunosuppressive regimen prior to a clinical event. However, these generally require significant laboratory processing and have had difficulty becoming established in common clinical use outside the research setting. One assay, Cylex ImmuKnow has been food and drug administration approved but has had variable results. In this review we discuss the assays that have been used to assess monitoring of immune function after liver transplantation and consider possible future directions.
Internal ID Number: 24669365
URI: http://ahro.austin.org.au/austinjspui/handle/1/12143
DOI: 10.5500/wjt.v4.i1.30
URL: http://www.ncbi.nlm.nih.gov/pubmed/24669365
Type: Journal Article
Subjects: Biomarkers
Immune function monitoring
Liver transplantation
Review
Appears in Collections:Journal articles

Files in This Item:
There are no files associated with this item.


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.