Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/12140
Title: The osteoblastic and osteoclastic interactions in spinal metastases secondary to prostate cancer.
Authors: Dushyanthen, Sathana;Cossigny, Davina A F;Quan, Gerald M Y
Affiliation: Spinal Biology Research Laboratory, Department of Spinal Surgery, University of Melbourne Department of Surgery, Austin Health, Heidelberg Victoria, Australia.
Issue Date: 27-Nov-2013
Citation: Cancer Growth and Metastasis 2013; 6(): 61-80
Abstract: Prostate cancer (PC) is one of the most common cancers arising in men and has a high propensity for bone metastasis, particularly to the spine. At this stage, it often causes severe morbidity due to pathological fracture and/or metastatic epidural spinal cord compression which, if untreated, inevitably leads to intractable pain, neurological deficit, and paralysis. Unfortunately, the underlying molecular mechanisms driving growth of secondary PC in the bony vertebral column remain largely unknown. Further investigation is warranted in order to identify therapeutic targets in the future. This review summarizes the current understanding of PC bone metastasis in the spine, highlighting interactions between key tumor and bone-derived factors which influence tumor progression, especially the functional roles of osteoblasts and osteoclasts in the bone microenvironment through their interactions with metastatic PC cells and the critical pathway RANK/RANKL/OPG in bone destruction.
Internal ID Number: 24665208
URI: http://ahro.austin.org.au/austinjspui/handle/1/12140
DOI: 10.4137/CGM.S12769
URL: http://www.ncbi.nlm.nih.gov/pubmed/24665208
Type: Journal Article
Subjects: OPG bone microenvironment
RANK
RANKL
metastasis
osteoblasts
osteoclasts
prostate cancer
spine
Appears in Collections:Journal articles

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