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|Title:||Mistaken identity: granular cell astrocytoma masquerading as histiocytosis of the central nervous system.|
|Authors:||Campbell, Robert N;Liew, Mun Sem;Gan, Hui K;Cher, Lawrence M|
|Affiliation:||Department of Neurology, Austin Health, Heidelberg, Victoria, Australia|
Joint Austin-Ludwig Oncology Unit, Olivia Newton John Cancer Wellness and Research Centre, Austin Health, Heidelberg, Victoria, Australia
|Citation:||Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia 2014; 21(8): 1457-9|
|Abstract:||Granular cell astrocytoma (GCA) is an uncommon malignant glial tumour that is associated with a poor prognosis. GCA cells have some morphological and immunohistochemical similarities to macrophages. In this case, a small biopsy contained no typical astrocytoma and large rounded lesional cells were interpreted as negative for glial fibrillary acidic protein and S100 and positive for CD68, a commonly used marker for macrophages. A diagnosis of a histiocytosis was made. When the patient failed to respond to first and second line therapy, tumour resection was undertaken and the pathology then showed typical morphologic and immunohistochemical features of glioblastoma (astrocytoma World Health Organization grade IV).|
|Internal ID Number:||24594450|
Granular cell astrocytoma
Magnetic Resonance Imaging
|Appears in Collections:||Journal articles|
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