Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/12107
Title: Mistaken identity: granular cell astrocytoma masquerading as histiocytosis of the central nervous system.
Authors: Campbell, Robert N;Liew, Mun Sem;Gan, Hui K;Cher, Lawrence M
Affiliation: Neurology Unit, Austin Health, VIC, Australia
Joint Austin-Ludwig Oncology Unit, Level 4 Olivia Newton-John Cancer & Wellness Centre, Austin Hospital, 145 Studley Road, Heidelberg, VIC 3084, Australia
Electronic address: lmcher@mac.com.
Issue Date: 6-Feb-2014
Citation: Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia 2014; 21(8): 1457-9
Abstract: Granular cell astrocytoma (GCA) is an uncommon malignant glial tumour that is associated with a poor prognosis. GCA cells have some morphological and immunohistochemical similarities to macrophages. In this case, a small biopsy contained no typical astrocytoma and large rounded lesional cells were interpreted as negative for glial fibrillary acidic protein and S100 and positive for CD68, a commonly used marker for macrophages. A diagnosis of a histiocytosis was made. When the patient failed to respond to first and second line therapy, tumour resection was undertaken and the pathology then showed typical morphologic and immunohistochemical features of glioblastoma (astrocytoma World Health Organization grade IV).
Internal ID Number: 24594450
URI: http://ahro.austin.org.au/austinjspui/handle/1/12107
DOI: 10.1016/j.jocn.2013.10.037
URL: http://www.ncbi.nlm.nih.gov/pubmed/24594450
Type: Journal Article
Subjects: Erdheim-Chester disease
Glioma
Granular cell astrocytoma
Astrocytoma.diagnosis.metabolism.pathology.surgery
Biological Markers.metabolism
Biopsy
Diagnosis, Differential
Fatal Outcome
Histiocytosis.diagnosis.drug therapy.metabolism.pathology
Humans
Immunohistochemistry
Magnetic Resonance Imaging
Male
Middle Aged
Neoplasm Grading
Appears in Collections:Journal articles

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