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Title: Orexinergic activation of medullary premotor neurons modulates the adrenal sympathoexcitation to hypothalamic glucoprivation.
Authors: Korim, Willian S;Bou Farah, Lama;McMullan, Simon;Verberne, Anthony J M
Affiliation: Clinical Pharmacology and Therapeutics Unit, Department of Medicine, Austin Health, University of Melbourne, Heidelberg, Victoria, Australia
Australian School of Advanced Medicine, Macquarie University, Sydney, New South Wales, Australia.
Clinical Pharmacology and Therapeutics Unit, Department of Medicine, Austin Health, University of Melbourne, Heidelberg, Victoria, Australia.
Issue Date: 18-Feb-2014
Citation: Diabetes 2014; 63(6): 1895-906
Abstract: Glucoprivation activates neurons in the perifornical hypothalamus (PeH) and in the rostral ventrolateral medulla (RVLM), which results in the release of adrenaline. The current study aimed to establish 1) whether neuroglucoprivation in the PeH or in the RVLM elicits adrenaline release in vivo and 2) whether direct activation by glucoprivation or orexin release in the RVLM modulates the adrenaline release. Neuroglucoprivation in the PeH or RVLM was elicited by microinjections of 2-deoxy-D-glucose or 5-thio-D-glucose in anesthetized, euglycemic rats. Firstly, inhibition of neurons in the PeH abolished the increase in adrenal sympathetic nerve activity (ASNA) to systemic glucoprivation. Secondly, glucoprivation of neurons in the PeH increased ASNA. Thirdly, in vivo or in vitro glucoprivation did not affect the activity of RVLM adrenal premotor neurons. Finally, blockade of orexin receptors in the RVLM abolished the increase in ASNA to neuroglucoprivation in the PeH. The evoked changes in ASNA were directly correlated to levels of plasma metanephrine but not to normetanephrine. These findings suggest that orexin release modulates the activation of adrenal presympathetic neurons in the RVLM.
Internal ID Number: 24550189
DOI: 10.2337/db13-1073
Type: Journal Article
Subjects: Adrenal Glands.metabolism
Dose-Response Relationship, Drug
Glucose.analogs & derivatives
Hypothalamus.drug effects.physiopathology
Medulla Oblongata.drug effects.physiopathology
Orexin Receptors.antagonists & inhibitors.metabolism
Rats, Sprague-Dawley
Sympathetic Nervous System.drug effects.physiopathology
Appears in Collections:Journal articles

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