Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/12065
Title: Effect of BDNF Val66Met on memory decline and hippocampal atrophy in prodromal Alzheimer's disease: a preliminary study.
Authors: Lim, Yen Ying;Villemagne, Victor L;Laws, Simon M;Ames, David;Pietrzak, Robert H;Ellis, Kathryn A;Harrington, Karra;Bourgeat, Pierrick;Bush, Ashley I;Martins, Ralph N;Masters, Colin L;Rowe, Christopher C;Maruff, Paul
Institutional Author: AIBL Research Group
Affiliation: Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, Australia ; Department of Nuclear Medicine and Centre for PET, Austin Health, Heidelberg, Victoria, Australia ; Department of Medicine, Austin Health, The University of Melbourne, Heidelberg, Victoria, Australia.
Centre of Excellence for Alzheimer's Disease Research and Care, School of Medical Sciences, Edith Cowan University, Joondalup, Western Australia, Australia ; Sir James McCusker Alzheimer's Disease Research Unit, Hollywood Private Hospital, Perth, Western Australia, Australia ; Co-operative Research Centre for Mental Health, Carlton South, Australia.
Academic Unit for Psychiatry of Old Age, Department of Psychiatry, The University of Melbourne, Kew, Victoria, Australia ; National Ageing Research Institute, Parkville, Victoria, Australia.
Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, United States of America.
Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, Australia ; Academic Unit for Psychiatry of Old Age, Department of Psychiatry, The University of Melbourne, Kew, Victoria, Australia ; National Ageing Research Institute, Parkville, Victoria, Australia.
Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, Australia.
Commonwealth Scientific Industrial Research Organization Preventative Health National Research Flagship, Australian e-Health Research Centre-BioMedIA, Brisbane, Queensland, Australia.
Centre of Excellence for Alzheimer's Disease Research and Care, School of Medical Sciences, Edith Cowan University, Joondalup, Western Australia, Australia ; Sir James McCusker Alzheimer's Disease Research Unit, Hollywood Private Hospital, Perth, Western Australia, Australia.
Department of Nuclear Medicine and Centre for PET, Austin Health, Heidelberg, Victoria, Australia ; Department of Medicine, Austin Health, The University of Melbourne, Heidelberg, Victoria, Australia.
Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, Australia ; CogState Ltd., Melbourne, Victoria, Australia.
Issue Date: 27-Jan-2014
Citation: Plos One 2014; 9(1): e86498
Abstract: Cross-sectional genetic association studies have reported equivocal results on the relationship between the brain-derived neurotrophic factor (BDNF) Val66Met and risk of Alzheimer's disease (AD). As AD is a neurodegenerative disease, genetic influences may become clearer from prospective study. We aimed to determine whether BDNF Val66Met polymorphism influences changes in memory performance, hippocampal volume, and Aβ accumulation in adults with amnestic mild cognitive impairment (aMCI) and high Aβ.Thirty-four adults with aMCI were recruited from the Australian, Imaging, Biomarkers and Lifestyle (AIBL) Study. Participants underwent PiB-PET and structural MRI neuroimaging, neuropsychological assessments and BDNF genotyping at baseline, 18 month, and 36 month assessments.In individuals with aMCI and high Aβ, Met carriers showed significant and large decline in episodic memory (d = 0.90, p = .020) and hippocampal volume (d = 0.98, p = .035). BDNF Val66Met was unrelated to the rate of Aβ accumulation (d = -0.35, p = .401).Although preliminary due to the small sample size, results of this study suggest that high Aβ levels and Met carriage may be useful prognostic markers of accelerated decline in episodic memory, and reductions in hippocampal volume in individuals in the prodromal or MCI stage of AD.
Internal ID Number: 24475133
URI: http://ahro.austin.org.au/austinjspui/handle/1/12065
DOI: 10.1371/journal.pone.0086498
URL: http://www.ncbi.nlm.nih.gov/pubmed/24475133
Type: Journal Article
Subjects: Aged
Aged, 80 and over
Alzheimer Disease.genetics
Amyloid beta-Peptides.metabolism
Atrophy
Australia
Brain-Derived Neurotrophic Factor.genetics
Cross-Sectional Studies
Female
Genetic Association Studies
Genotype
Hippocampus.pathology
Humans
Magnetic Resonance Imaging
Male
Memory Disorders.genetics
Mild Cognitive Impairment.genetics.pathology
Mutation, Missense.genetics
Positron-Emission Tomography
Appears in Collections:Journal articles

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