Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/12063
Title: 18F-fluorodeoxyglucose--positron emission tomography/computed tomography aids staging and predicts mortality in patients with muscle-invasive bladder cancer.
Authors: Mertens, Laura S;Mir, M Carmen;Scott, Andrew M;Lee, Sze Ting;Fioole-Bruining, Annemarie;Vegt, Erik;Vogel, Wouter V;Manecksha, Rustom;Bolton, Damien M;Davis, Ian D;Horenblas, Simon;van Rhijn, Bas W G;Lawrentschuk, Nathan
Affiliation: Department of Urology, The Netherlands Cancer Institute, Amsterdam, The Netherlands. Electronic address: b.v.rhijn@nki.nl.
Department of Medicine, Ludwig Institute for Cancer Research, University of Melbourne and Center for PET, Austin Hospital, Melbourne, Australia.
Department of Radiology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Department of Nuclear Medicine, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Department of Surgery, Ludwig Institute for Cancer Research, University of Melbourne and Center for PET, Austin Hospital, Melbourne, Australia.
Joint Medical Oncology Unit, Austin Hospital, Melbourne, Australia.
Department of Urology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Issue Date: 1-Feb-2014
Citation: Urology; 83(2): 393-8
Abstract: To investigate the association between extravesical (18)F-fluorodeoxyglucose (FDG) avid lesions on FDG-positron emission tomography/computed tomography (PET/CT) and mortality in patients with muscle-invasive bladder cancer.An international, bi-institutional cohort study of 211 patients with muscle-invasive bladder cancer who underwent staging CT and FDG-PET/CT imaging. On the basis of the presence of extravesical FDG-avid lesions suspicious for malignancy on PET/CT images, patients were divided into a PET/CT-positive and PET/CT-negative group. Data on staging and mortality were retrospectively analyzed from prospective databases. Kaplan-Meier analyses were performed to compare overall (OS) and disease-specific survival (DSS) between the groups. Multivariable Cox regression models were used to investigate the association between extravesical PET/CT lesions and mortality. Extravesical lesions suspicious for malignancy on conventional CT were included in the models.Of the 211 patients, 98 (46.4%) had 1 or more extravesical lesions on PET/CT, 113 (53.5%) had a negative PET/CT. Conventional CT revealed extravesical lesions in 51 patients (24.4%). Median follow-up was 18 months. Patients with a positive PET/CT had a significantly shorter OS and DSS (median OS: 14 vs 50 months, P = .001; DSS: 16 vs 50 months, P <.001). In multivariable analysis, the presence of extravesical lesions on PET/CT was an independent prognostic indicator of mortality (OS: hazard ratio = 3.0, confidence interval 95% 1.7-5.1). This association was not statistically significant for conventional CT (hazard ratio = 1.6 (95% confidence interval 0.9-2.7).On the basis of our results, the presence of extravesical FDG-avid lesions on PET/CT might be considered an independent indicator of mortality.
Internal ID Number: 24468513
URI: http://ahro.austin.org.au/austinjspui/handle/1/12063
DOI: 10.1016/j.urology.2013.10.032
URL: http://www.ncbi.nlm.nih.gov/pubmed/24468513
Type: Journal Article
Subjects: Aged
Cohort Studies
Female
Fluorodeoxyglucose F18.diagnostic use
Humans
Male
Multimodal Imaging
Muscle, Smooth
Neoplasm Invasiveness
Neoplasm Staging
Positron-Emission Tomography
Predictive Value of Tests
Prognosis
Radiopharmaceuticals.diagnostic use
Retrospective Studies
Tomography, X-Ray Computed
Urinary Bladder Neoplasms.diagnosis.mortality.pathology
Appears in Collections:Journal articles

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