Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/12030
Title: FOXP3 over-expression inhibits melanoma tumorigenesis via effects on proliferation and apoptosis.
Authors: Tan, BeeShin;Anaka, Matthew;Deb, Siddhartha;Freyer, Claudia;Ebert, Lisa M;Chueh, Anderly C;Al-Obaidi, Sheren;Behren, Andreas;Jayachandran, Aparna;Cebon, Jonathan S;Chen, Weisan;Mariadason, John M
Affiliation: Ludwig Institute for Cancer Research Ltd. Melbourne-Austin Branch, Heidelberg, Victoria, Australia.
Issue Date: 15-Jan-2014
Citation: Oncotarget; 5(1): 264-76
Abstract: The Forkhead box P3 (FOXP3) transcription factor is the key driver of regulatory T cell (Treg cells) differentiation and immunosuppressive function. In addition, FOXP3 has been reported to be expressed in many tumors, including melanoma. However, its role in tumorigenesis is conflicting, with both tumor suppressive and tumor promoting functions described. The aim of the current study was to characterize the expression and function of FOXP3 in melanoma. FOXP3 expression was detected by immunohistochemistry (IHC) in 12% (18/146) of stage III and IV melanomas. However expression was confined to fewer than 1% of cells in these tumors. Stable over-expression of FOXP3 in the SK-MEL-28 melanoma cell line reduced cell proliferation and clonogenicity in vitro, and reduced xenograft growth in vivo. FOXP3 over-expression also increased pigmentation and the rate of apoptosis of SK-MEL-28 cells. Based on its infrequent expression in human melanoma, and its growth inhibitory and pro-apoptotic effect in over-expressing melanoma cells, we conclude that FOXP3 is not likely to be a key tumor suppressor or promoter in melanoma.
Internal ID Number: 24406338
URI: http://ahro.austin.org.au/austinjspui/handle/1/12030
URL: http://www.ncbi.nlm.nih.gov/pubmed/24406338
Type: Journal Article
Subjects: Animals
Apoptosis.physiology
Carcinogenesis
Cell Growth Processes.physiology
Cell Line, Tumor
Forkhead Transcription Factors.biosynthesis.genetics
Humans
Melanoma.genetics.metabolism.pathology
Mice
Mice, Inbred BALB C
Mice, Nude
Neoplasm Metastasis
Transfection
Appears in Collections:Journal articles

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