Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/12011
Title: Changes to volumetric bone mineral density and bone strength after stroke: a prospective study.
Authors: Borschmann, Karen;Pang, Marco Y C;Iuliano, Sandra;Churilov, Leonid;Brodtmann, Amy;Ekinci, Elif I;Bernhardt, Julie
Affiliation: School of Health Science, Latrobe University, Melbourne, Victoria, Australia
Stroke Division, Florey Institute of Neuroscience and Mental Health, the University of Melbourne, Heidelberg, Victoria, Australia
Issue Date: 23-Dec-2013
Citation: International Journal of Stroke : Official Journal of the International Stroke Society 2013; 10(3): 396-9
Abstract: Stroke survivors experience accelerated bone loss and increased fracture risk, particularly in paretic weight bearing limbs. Understanding how these changes unfold and their relationship to stroke severity and physical activity could help in the development of targeted interventions to prevent or reduce the severity of these outcomes. The primary aim of this study is to investigate the time course and magnitude of changes in volumetric bone mineral density within the first year after stroke, and to examine relationships with physical activity and motor recovery.This is a prospective, observational study of 43 nondiabetic, nonambulant adults with first ever hemispheric stroke.The primary outcome was the difference in six-month change of total volumetric bone mineral density between paretic and nonparetic distal tibiae, measured at 7% of bone length site using high-resolution peripheral quantitative computed tomography.The secondary outcomes are cortical and trabecular volumetric bone mineral density, cortical thickness, and total and cross-sectional areas of distal tibiae and radii of paretic and nonparetic limbs. Also included are total body and regional bone mineral density derived using dual-energy X-ray absorptiometry, physical activity measured using accelerometry, and motor recovery (Chedoke McMaster Stroke Assessment).Measuring the timing and magnitude of changes to volumetric bone mineral density and bone structure from immediately after stroke, and relationships between these changes with physical activity and motor recovery will provide the basis for targeted interventions to reduce fracture risk in stroke survivors.
Internal ID Number: 24373530
URI: http://ahro.austin.org.au/austinjspui/handle/1/12011
DOI: 10.1111/ijs.12228
ORCID: 0000-0002-9807-6606
0000-0003-2372-395X
0000-0003-2543-8722
URL: http://www.ncbi.nlm.nih.gov/pubmed/24373530
Type: Journal Article
Subjects: HR-pQCT
bone mineral density
bone structure
fracture
physical activity
stroke
Appears in Collections:Journal articles

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