Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/11978
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dc.contributor.authorFujii, Tomokoen
dc.contributor.authorUchino, Shigehikoen
dc.contributor.authorTakinami, Masanorien
dc.contributor.authorBellomo, Rinaldoen
dc.date.accessioned2015-05-16T01:36:48Z
dc.date.available2015-05-16T01:36:48Z
dc.date.issued2013-12-05en
dc.identifier.citationClinical Journal of the American Society of Nephrology : Cjasn 2013; 9(3): 457-61en
dc.identifier.govdoc24311710en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/11978en
dc.description.abstractThe epidemiology of AKI and CKD has been described. However, the epidemiology of progressively worsening kidney function (subacute kidney injury [s-AKI]) developing over a longer time frame than defined for AKI (7 days), but shorter than defined for CKD (90 days), is completely unknown.This retrospective study used a hospital laboratory and admission database. Adult patients admitted to a teaching hospital in Tokyo, Japan, between April 1, 2008, and October 31, 2011, were included. s-AKI was classified into three grades of severity (mild, moderate, severe) in accordance with the Risk, Injury, and Failure categories of the Risk, Injury, Failure, Risk, Loss, and ESRD classification, but did not use its time frame. Kidney injury (AKI and s-AKI) occurring during each hospital stay was identified, and logistic regression analysis was performed to assess their effect on hospital mortality.Of 56,567 patients admitted to the hospital during the study period, 49,518 were included. Of these, 87.8% had no evidence of kidney dysfunction, 11.0% had AKI, and 1.1% had s-AKI. Patients with s-AKI had mild renal dysfunction in 82.7% of cases, moderate in 12.1%, and severe in 5.0%. Worsening s-AKI category was linearly correlated with hospital mortality, as previously described for AKI (no injury: 1.2%, mild: 6.5%, moderate: 12.9%, severe: 20.7%). Although mortality (8.0% versus 17.5%) and need for renal replacement therapy (0.2% versus 2.2%) were lower in patients with s-AKI than in those with AKI, multivariable regression analysis confirmed that s-AKI was an independent risk factor for hospital mortality (odds ratio (OR), 5.44; 95% confidence interval [95% CI], 3.89 to 7.44); the OR with AKI was 14.8 (95% CI, 13.2 to 16.7).Close to 1% of hospitalized patients develop s-AKI. This condition is independently associated with increased hospital mortality, and the risk for death increases with s-AKI severity. Patients with s-AKI had a better outcome and were less likely to require renal replacement therapy than patients with AKI.en
dc.language.isoenen
dc.subject.otherAcute Kidney Injury.diagnosis.epidemiology.physiopathologyen
dc.subject.otherAdulten
dc.subject.otherAgeden
dc.subject.otherFemaleen
dc.subject.otherHospital Mortalityen
dc.subject.otherHospitalizationen
dc.subject.otherHospitals, Teachingen
dc.subject.otherHumansen
dc.subject.otherJapan.epidemiologyen
dc.subject.otherKidney.physiopathologyen
dc.subject.otherKidney Diseases.diagnosis.epidemiology.mortality.physiopathology.therapyen
dc.subject.otherLogistic Modelsen
dc.subject.otherMaleen
dc.subject.otherMiddle Ageden
dc.subject.otherMultivariate Analysisen
dc.subject.otherOdds Ratioen
dc.subject.otherPrognosisen
dc.subject.otherRenal Replacement Therapyen
dc.subject.otherRetrospective Studiesen
dc.subject.otherRisk Assessmenten
dc.subject.otherRisk Factorsen
dc.subject.otherSeverity of Illness Indexen
dc.subject.otherTime Factorsen
dc.titleSubacute kidney injury in hospitalized patients.en
dc.typeJournal Articleen
dc.identifier.journaltitleClinical journal of the American Society of Nephrology : CJASNen
dc.identifier.affiliationIntensive Care Unit, Department of Anesthesiology, The Jikei University School of Medicine, Tokyo, Japan, †Department of Intensive Care, Austin Hospital, Melbourne, Victoria, Australiaen
dc.identifier.doi10.2215/CJN.04120413en
dc.description.pages457-61en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/24311710en
dc.type.austinJournal Articleen
local.name.researcherBellomo, Rinaldo
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptIntensive Care-
crisitem.author.deptData Analytics Research and Evaluation (DARE) Centre-
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