Please use this identifier to cite or link to this item:
Title: Preoperative urinary neutrophil gelatinase-associated lipocalin and outcome in high-risk heart failure patients undergoing cardiac surgery.
Authors: Silvetti, Simona;Meroni, Roberta;Bignami, Elena;Bove, Tiziana;Landoni, Giovanni;Zangrillo, Alberto;Bellomo, Rinaldo;Pappalardo, Federico
Affiliation: Department of Anesthesia and Intensive Care, San Raffaele Scientific Institute, Milano, Italy.
Department of Anesthesia and Intensive Care, San Raffaele Scientific Institute, Milano, Italy. Electronic address:
Departments of Intensive Care and Cardiac Surgery, Austin Health, Melbourne, Australia.
Issue Date: 2-Dec-2013
Citation: Journal of Cardiothoracic and Vascular Anesthesia 2013; 28(2): 323-7
Abstract: To investigate the ability of early urinary neutrophil gelatinase-associated lipocalin to predict postoperative complications in adult patients with ventricular dysfunction undergoing cardiac surgery.Prospective observational study.Single-center study, university hospital.Fifty-six adult high-risk cardiac surgical patients with preoperative cardiac failure.None.Demographic and clinical characteristics were obtained, and neutrophil gelatinase-associated lipocalin was measured at baseline and at several time points after surgery. Patient characteristics and neutrophil gelatinase-associated lipocalin levels were related to renal and patient outcome. On multivariate analyses, preoperative urinary neutrophil gelatinase-associated lipocalin was an independent predictor of length of intensive care stay (p = 0.004) and in-hospital stay (p = 0.04), but not of acute kidney injury or renal replacement therapy and was not associated with baseline renal function.In a cohort of high-risk cardiac surgery patients, preoperative urinary neutrophil gelatinase-associated lipocalin value provided prognostic information that was independent of the onset of acute kidney injury or of preoperative renal function.
Internal ID Number: 24295718
DOI: 10.1053/j.jvca.2013.07.007
Type: Journal Article
Subjects: acute kidney injury
cardiac surgery
intensive care
neutrophil gelatinase-associated lipocalin
Acute Kidney Injury.urine
Acute-Phase Proteins.urine
Aged, 80 and over
Biological Markers.urine
Cardiac Output, Low.etiology
Cardiac Surgical Procedures.methods
Cardiotonic Agents.therapeutic use
Intensive Care
Intra-Aortic Balloon Pumping
Kidney Function Tests
Length of Stay
Linear Models
Middle Aged
Predictive Value of Tests
Proto-Oncogene Proteins.urine
Renal Replacement Therapy
Risk Assessment
Treatment Outcome
Appears in Collections:Journal articles

Files in This Item:
There are no files associated with this item.

Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.