Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/11972
Title: Preoperative urinary neutrophil gelatinase-associated lipocalin and outcome in high-risk heart failure patients undergoing cardiac surgery.
Authors: Silvetti, Simona;Meroni, Roberta;Bignami, Elena;Bove, Tiziana;Landoni, Giovanni;Zangrillo, Alberto;Bellomo, Rinaldo;Pappalardo, Federico
Affiliation: Department of Anesthesia and Intensive Care, San Raffaele Scientific Institute, Milano, Italy.
Department of Anesthesia and Intensive Care, San Raffaele Scientific Institute, Milano, Italy. Electronic address: landoni.giovanni@hsr.it.
Departments of Intensive Care and Cardiac Surgery, Austin Health, Melbourne, Australia.
Issue Date: 2-Dec-2013
Citation: Journal of Cardiothoracic and Vascular Anesthesia 2013; 28(2): 323-7
Abstract: To investigate the ability of early urinary neutrophil gelatinase-associated lipocalin to predict postoperative complications in adult patients with ventricular dysfunction undergoing cardiac surgery.Prospective observational study.Single-center study, university hospital.Fifty-six adult high-risk cardiac surgical patients with preoperative cardiac failure.None.Demographic and clinical characteristics were obtained, and neutrophil gelatinase-associated lipocalin was measured at baseline and at several time points after surgery. Patient characteristics and neutrophil gelatinase-associated lipocalin levels were related to renal and patient outcome. On multivariate analyses, preoperative urinary neutrophil gelatinase-associated lipocalin was an independent predictor of length of intensive care stay (p = 0.004) and in-hospital stay (p = 0.04), but not of acute kidney injury or renal replacement therapy and was not associated with baseline renal function.In a cohort of high-risk cardiac surgery patients, preoperative urinary neutrophil gelatinase-associated lipocalin value provided prognostic information that was independent of the onset of acute kidney injury or of preoperative renal function.
Internal ID Number: 24295718
URI: http://ahro.austin.org.au/austinjspui/handle/1/11972
DOI: 10.1053/j.jvca.2013.07.007
URL: http://www.ncbi.nlm.nih.gov/pubmed/24295718
Type: Journal Article
Subjects: acute kidney injury
cardiac surgery
intensive care
neutrophil gelatinase-associated lipocalin
Acute Kidney Injury.urine
Acute-Phase Proteins.urine
Aged
Aged, 80 and over
Biological Markers.urine
Cardiac Output, Low.etiology
Cardiac Surgical Procedures.methods
Cardiotonic Agents.therapeutic use
Female
Heart Failure.surgery.urine
Humans
Intensive Care
Intra-Aortic Balloon Pumping
Kidney Function Tests
Length of Stay
Linear Models
Lipocalins.urine
Luminescence
Male
Middle Aged
Predictive Value of Tests
Prognosis
Proto-Oncogene Proteins.urine
Renal Replacement Therapy
Risk Assessment
Treatment Outcome
Ventricular Dysfunction.surgery
Appears in Collections:Journal articles

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