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dc.contributor.authorTomasini, Arnauden
dc.contributor.authorFrançois, Patriceen
dc.contributor.authorHowden, Benjamin Pen
dc.contributor.authorFechter, Pierreen
dc.contributor.authorRomby, Pascaleen
dc.contributor.authorCaldelari, Isabelleen
dc.identifier.citationInfection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases 2013; 21(): 616-26en
dc.description.abstractRNA molecules with regulatory functions in pathogenic bacteria have benefited from a renewed interest these two last decades. In Staphylococcus aureus, recent genome-wide approaches have led to the discovery that almost 10-20% of genes code for RNAs with critical regulatory roles in adaptive processes. These RNAs include trans-acting RNAs, which mostly act through binding to target mRNAs, and cis-acting RNAs, which include regulatory regions of mRNAs responding to various metabolic signals. Besides recent analysis of S. aureus transcriptome has revealed an unprecedented existence of pervasive transcription generating a high number of weakly expressed antisense RNAs along the genome as well as numerous mRNAs with overlapped regions. Here, we will illustrate the diversity of trans-acting RNAs and illustrate how they are integrated into complex regulatory circuits, which link metabolism, stress response and virulence.en
dc.subject.otherRegulatory RNAen
dc.subject.otherGene Expression Regulation, Bacterialen
dc.subject.otherRNA, Bacterial.genetics.metabolismen
dc.subject.otherRNA, Small Untranslated.genetics.metabolismen
dc.subject.otherStaphylococcus aureus.genetics.pathogenicityen
dc.subject.otherStress, Physiologicalen
dc.subject.otherVirulence Factors.geneticsen
dc.titleThe importance of regulatory RNAs in Staphylococcus aureus.en
dc.typeJournal Articleen
dc.identifier.journaltitleInfection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseasesen
dc.identifier.affiliationDepartment of Microbiology, Austin Health, Heidelberg, Victoria, Australiaen
dc.identifier.affiliationAustin Centre for Infection Research (ACIR), Infectious Diseases Department, Austin Health, Heidelberg, Victoria, Australiaen
dc.identifier.affiliationDepartment of Microbiology, Monash University, Clayton, Victoria, Australiaen
dc.identifier.affiliationDepartment of Microbiology and Immunology, University of Melbourne, Parkville, Victoria, Australiaen
dc.identifier.affiliationArchitecture et Réactivité de l'ARN, Université de Strasbourg, CNRS, IBMC, Strasbourg, France.en
dc.identifier.affiliationGenomic Research Laboratory, Department of Medical Specialties, Geneva University Hospitals, University of Geneva, Genève, Switzerland.en
dc.identifier.affiliationArchitecture et Réactivité de l'ARN, Université de Strasbourg, CNRS, IBMC, Strasbourg, Franceen
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