Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/11971
Title: The importance of regulatory RNAs in Staphylococcus aureus.
Authors: Tomasini, Arnaud;François, Patrice;Howden, Benjamin P;Fechter, Pierre;Romby, Pascale;Caldelari, Isabelle
Affiliation: Microbiology Department, Austin Health, Heidelberg, Victoria, Australia
Austin Centre for Infection Research (ACIR), Infectious Diseases Department, Austin Health, Heidelberg, Victoria, Australia
Department of Microbiology, Monash University, Clayton, Victoria, Australia
Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria, Australia
Architecture et Réactivité de l'ARN, Université de Strasbourg, CNRS, IBMC, Strasbourg, France.
Genomic Research Laboratory, Department of Medical Specialties, Geneva University Hospitals, University of Geneva, Genève, Switzerland.
Architecture et Réactivité de l'ARN, Université de Strasbourg, CNRS, IBMC, Strasbourg, France. Electronic address: I.caldelari@ibmc-cnrs.unistra.fr.
Issue Date: 27-Nov-2013
Citation: Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases 2013; 21(): 616-26
Abstract: RNA molecules with regulatory functions in pathogenic bacteria have benefited from a renewed interest these two last decades. In Staphylococcus aureus, recent genome-wide approaches have led to the discovery that almost 10-20% of genes code for RNAs with critical regulatory roles in adaptive processes. These RNAs include trans-acting RNAs, which mostly act through binding to target mRNAs, and cis-acting RNAs, which include regulatory regions of mRNAs responding to various metabolic signals. Besides recent analysis of S. aureus transcriptome has revealed an unprecedented existence of pervasive transcription generating a high number of weakly expressed antisense RNAs along the genome as well as numerous mRNAs with overlapped regions. Here, we will illustrate the diversity of trans-acting RNAs and illustrate how they are integrated into complex regulatory circuits, which link metabolism, stress response and virulence.
Internal ID Number: 24291227
URI: http://ahro.austin.org.au/austinjspui/handle/1/11971
DOI: 10.1016/j.meegid.2013.11.016
URL: http://www.ncbi.nlm.nih.gov/pubmed/24291227
Type: Journal Article
Subjects: Regulatory RNA
Staphylococcus
Virulence
Gene Expression Regulation, Bacterial
RNA, Bacterial.genetics.metabolism
RNA, Small Untranslated.genetics.metabolism
Staphylococcus aureus.genetics.pathogenicity
Stress, Physiological
Virulence Factors.genetics
Appears in Collections:Journal articles

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