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|Title:||The importance of regulatory RNAs in Staphylococcus aureus.|
|Authors:||Tomasini, Arnaud;François, Patrice;Howden, Benjamin P;Fechter, Pierre;Romby, Pascale;Caldelari, Isabelle|
|Affiliation:||Architecture et Réactivité de l'ARN, Université de Strasbourg, CNRS, IBMC, Strasbourg, France.|
Genomic Research Laboratory, Department of Medical Specialties, Geneva University Hospitals, University of Geneva, Genève, Switzerland.
Austin Centre for Infection Research (ACIR), Infectious Diseases Department, Austin Health, Heidelberg, Victoria, Australia; Microbiology Department, Austin Health, Heidelberg, Victoria, Australia; Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria, Australia; Department of Microbiology, Monash University, Clayton, Victoria, Australia.
Architecture et Réactivité de l'ARN, Université de Strasbourg, CNRS, IBMC, Strasbourg, France. Electronic address: I.email@example.com.
|Citation:||Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases 2013; 21(): 616-26|
|Abstract:||RNA molecules with regulatory functions in pathogenic bacteria have benefited from a renewed interest these two last decades. In Staphylococcus aureus, recent genome-wide approaches have led to the discovery that almost 10-20% of genes code for RNAs with critical regulatory roles in adaptive processes. These RNAs include trans-acting RNAs, which mostly act through binding to target mRNAs, and cis-acting RNAs, which include regulatory regions of mRNAs responding to various metabolic signals. Besides recent analysis of S. aureus transcriptome has revealed an unprecedented existence of pervasive transcription generating a high number of weakly expressed antisense RNAs along the genome as well as numerous mRNAs with overlapped regions. Here, we will illustrate the diversity of trans-acting RNAs and illustrate how they are integrated into complex regulatory circuits, which link metabolism, stress response and virulence.|
|Internal ID Number:||24291227|
Gene Expression Regulation, Bacterial
RNA, Small Untranslated.genetics.metabolism
|Appears in Collections:||Journal articles|
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