Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/11949
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dc.contributor.authorHowells, David Williamen
dc.contributor.authorSena, Emily Sen
dc.contributor.authorMacleod, Malcolm Ren
dc.date.accessioned2015-05-16T01:35:00Z
dc.date.available2015-05-16T01:35:00Z
dc.date.issued2013-11-19en
dc.identifier.citationNature Reviews. Neurology 2013; 10(1): 37-43en
dc.identifier.govdoc24247324en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/11949en
dc.description.abstractTranslational neuroscience is in the doldrums. The stroke research community was among the first to recognize that the motivations inherent in our system of research can cause investigators to take shortcuts, and can introduce bias and reduce generalizability, all of which leads ultimately to the recurrent failure of apparently useful drug candidates in clinical trials. Here, we review the evidence for these problems in stroke research, where they have been most studied, and in other translational research domains, which seem to be bedevilled by the same issues. We argue that better scientific training and simple changes to the way that we fund, assess and publish research findings could reduce wasted investment, speed drug development, and create a healthier research environment. For 'phase III' preclinical studies--that is, those studies that build the final justification for conducting a clinical trial--we argue for a need to apply the same attention to detail, experimental rigour and statistical power in our animal experiments as in the clinical trials themselves.en
dc.language.isoenen
dc.subject.otherAnimalsen
dc.subject.otherHumansen
dc.subject.otherStroke.diagnosis.therapyen
dc.subject.otherTranslational Medical Researchen
dc.titleBringing rigour to translational medicine.en
dc.typeJournal Articleen
dc.identifier.journaltitleNature reviews. Neurologyen
dc.identifier.affiliationDepartment of Clinical Neurosciences, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, UKen
dc.identifier.affiliationFlorey Institute of Neuroscience and Mental Health, 245 Burgundy Street, Heidelberg, Vic 3084, Australiaen
dc.identifier.doi10.1038/nrneurol.2013.232en
dc.description.pages37-43en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/24247324en
dc.type.austinJournal Articleen
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
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