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Title: High dietary taurine inhibits myocardial apoptosis during an atherogenic diet: association with increased myocardial HSP70 and HSF-1 but not caspase 3.
Authors: Setyarani, M;Zinellu, A;Carru, C;Zulli, Anthony
Affiliation: Department of Medicine, Austin Health, University of Melbourne, Melbourne, VIC, Australia
Issue Date: 22-Oct-2013
Citation: European Journal of Nutrition 2013; 53(3): 929-37
Abstract: Apoptosis is a major cause of myocyte death, and taurine is anti-apoptotic. Heat shock protein 70 (HSP70) (which is regulated by heat shock factor-HSF-1) is also anti-apoptotic, and caspase 3 stimulates the apoptotic pathway. This study investigated whether taurine affects atherogenic diet-induced myocardial apoptosis, and whether HSP70, HSF-1 and caspase 3 are involved.New Zealand white rabbits were divided into 3 groups for 4 weeks according to their diet. Group 1 (control) was fed a normal rabbit diet; Group 2 (MC) received a normal rabbit diet with 1% methionine plus 0.5% cholesterol. Group 3 received MC diet + 2.5% taurine (MCT).The atherogenic diet did not affect myocardial HSP70 or HSF-1 protein, but increased myocardial apoptotic nuclei to 40% (p < 0.01) versus 7% in con and 12% in MCT (p < 0.01). However, in MCT, myocardial HSP70 expression increased by 42.7% versus con and MC (p = 0.016), HSF-1 by 12% versus con and MC (p < 0.05), and total nuclei count increased by 37% versus MC (p < 0.05). Caspase 3 subunits remained unchanged in all groups, and HSP70 was increased approximately twofold in endothelial layer of arterioles (p = 0.01).This study shows that taurine could reduce myocardial apoptotic nuclei and thus confer myocardial cytoprotection via stimulating myocardial HSP70 via HSF-1 and caspase 3-independent mechanisms.
Internal ID Number: 24146099
DOI: 10.1007/s00394-013-0596-5
Type: Journal Article
Subjects: Animals
Antioxidants.therapeutic use
Atherosclerosis.etiology.metabolism.pathology.prevention & control
Cardiotonic Agents.therapeutic use
Caspase 3.metabolism
Coronary Vessels.enzymology.metabolism.pathology
DNA-Binding Proteins.agonists.metabolism
Diet, Atherogenic.adverse effects
Dietary Supplements
Endothelium, Vascular.enzymology.metabolism.pathology
HSP70 Heat-Shock Proteins.agonists.metabolism
Oxidative Stress
Random Allocation
Taurine.therapeutic use
Transcription Factors.agonists.metabolism
Appears in Collections:Journal articles

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