Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/11905
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dc.contributor.authorNg Tang Fui, Men
dc.contributor.authorHoermann, Rudolfen
dc.contributor.authorCheung, Ada Sen
dc.contributor.authorGianatti, Emily Jen
dc.contributor.authorZajac, J Den
dc.contributor.authorGrossmann, Mathisen
dc.date.accessioned2015-05-16T01:32:15Z
dc.date.available2015-05-16T01:32:15Z
dc.date.issued2013-09-30en
dc.identifier.citationAndrology 2013; 1(6): 906-12en
dc.identifier.govdoc24115523en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/11905en
dc.description.abstractAlthough men with type 2 diabetes (T2D) frequently have lowered testosterone levels, it is not well established whether this is ascribable to the diabetic state per se, or because of other factors, such as obesity. Our objective was to determine the prevalence and correlates of low testosterone in middle-aged men with diabetes. We conducted a cross-sectional study in 240 men including 80 men with type 1 diabetes (T1D), 80 men with T2D and 80 men without diabetes. Prevalence of a total testosterone ≤8 nmol/L was low, occurring in none of the men with T1D, 6.2% of men with T2D and 2.5% of men without diabetes. Men with T1D had higher testosterone levels compared with men without diabetes (p < 0.001), even after adjustment for body mass index (BMI) and age (p < 0.02). While men with T2D had lower testosterone compared with controls (p = 0.03), this was no longer significant when BMI and age were taken into account (p = 0.16). In the entire cohort, TT remained inversely associated with BMI independent of age, sex hormone-binding globulin and diabetic status (p = 0.01), whereas calculated free testosterone (cFT) was independently and inversely associated with age (p < 0.001), but not with BMI (p = 0.47). These results suggest that marked reductions in circulating testosterone are uncommon in middle-aged men with diabetes. Increasing BMI and age are dominant drivers of lowered total and cFT, respectively, independent of the presence or absence of diabetes.en
dc.language.isoenen
dc.subject.otherageingen
dc.subject.otherdiabetesen
dc.subject.otherobesityen
dc.subject.othertestosteroneen
dc.subject.otherAdulten
dc.subject.otherAgeden
dc.subject.otherBody Mass Indexen
dc.subject.otherCross-Sectional Studiesen
dc.subject.otherDiabetes Mellitus, Type 1.blood.complicationsen
dc.subject.otherDiabetes Mellitus, Type 2.blood.complicationsen
dc.subject.otherHumansen
dc.subject.otherMaleen
dc.subject.otherMiddle Ageden
dc.subject.otherObesity.complications.epidemiologyen
dc.subject.otherPrevalenceen
dc.subject.otherSex Hormone-Binding Globulin.analysisen
dc.subject.otherTestosterone.blooden
dc.subject.otherVictoria.epidemiologyen
dc.titleObesity and age as dominant correlates of low testosterone in men irrespective of diabetes status.en
dc.typeJournal Articleen
dc.identifier.journaltitleAndrologyen
dc.identifier.affiliationDepartment of Medicine, Austin Health, The University of Melbourne, Heidelberg, Vic., Australia; Department of Endocrinology, Austin Health, Heidelberg, Vic., Australia.en
dc.identifier.doi10.1111/j.2047-2927.2013.00124.xen
dc.description.pages906-12en
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pubmed/24115523en
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