Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/11892
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dc.contributor.authorCalamante, Fernandoen
dc.date.accessioned2015-05-16T01:31:26Z
dc.date.available2015-05-16T01:31:26Z
dc.date.issued2013-05-11en
dc.identifier.citationProgress in Nuclear Magnetic Resonance Spectroscopy 2013; 74(): 1-32en
dc.identifier.govdoc24083460en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/11892en
dc.description.abstractCerebral perfusion, also referred to as cerebral blood flow (CBF), is one of the most important parameters related to brain physiology and function. The technique of dynamic-susceptibility contrast (DSC) MRI is currently the most commonly used MRI method to measure perfusion. It relies on the intravenous injection of a contrast agent and the rapid measurement of the transient signal changes during the passage of the bolus through the brain. Central to quantification of CBF using this technique is the so-called arterial input function (AIF), which describes the contrast agent input to the tissue of interest. Due to its fundamental role, there has been a lot of progress in recent years regarding how and where to measure the AIF, how it influences DSC-MRI quantification, what artefacts one should avoid, and the design of automatic methods to measure the AIF. The AIF is also directly linked to most of the major sources of artefacts in CBF quantification, including partial volume effect, bolus delay and dispersion, peak truncation effects, contrast agent non-linearity, etc. While there have been a number of good review articles on DSC-MRI over the years, these are often comprehensive but, by necessity, with limited in-depth discussion of the various topics covered. This review article covers in greater depth the issues associated with the AIF and their implications for perfusion quantification using DSC-MRI.en
dc.language.isoenen
dc.subject.otherArterial input functionen
dc.subject.otherCerebral blood flowen
dc.subject.otherContrast agenten
dc.subject.otherDeconvolutionen
dc.subject.otherDynamic susceptibility contrasten
dc.subject.otherPerfusionen
dc.subject.otherBrain.anatomy & histology.blood supply.physiologyen
dc.subject.otherCerebrovascular Circulation.physiologyen
dc.subject.otherContrast Media.chemistryen
dc.subject.otherHumansen
dc.subject.otherMagnetic Resonance Imaging.methodsen
dc.titleArterial input function in perfusion MRI: a comprehensive review.en
dc.typeJournal Articleen
dc.identifier.journaltitleProgress in nuclear magnetic resonance spectroscopyen
dc.identifier.affiliationDepartment of Medicine, Austin Health and Northern Health, University of Melbourne, Melbourne, Victoria, Australiaen
dc.identifier.affiliationFlorey Institute of Neuroscience and Mental Health, Heidelberg, Victoria, Australiaen
dc.identifier.doi10.1016/j.pnmrs.2013.04.002en
dc.description.pages1-32en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/24083460en
dc.type.austinJournal Articleen
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
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