Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/11869
Title: Intrathecal kynurenate reduces arterial pressure, heart rate and baroreceptor-heart rate reflex in conscious rats.
Authors: Verberne, Anthony J M;Widdop, Robert E;Maccarrone, C;Jarrott, B;Beart, P M;Louis, William J
Affiliation: University of Melbourne, Clinical Pharmacology and Therapeutics Unit, Austin Hospital, Heidelberg, Vic., Australia.
Issue Date: 13-Jul-1990
Citation: Neuroscience Letters; 114(3): 309-15
Abstract: In the present study, an excitatory amino acid (EAA) pathway in the spinal cord which maintains sympathetic vasomotor tone in conscious rats has been investigated. To this end, the cardiovascular effects of an intrathecally administered EAA antagonist, kynurenate (KYN), were studied in conscious rats. KYN (0.5 mumol in 10 microliters) caused a dramatic reduction in mean arterial pressure (MAP) and heart rate (HR) that persisted for 2-3 h, and also resulted in extensor paralysis of the hindlimbs. The time courses of fall in MAP and HR and hindlimb paralysis were similar. Baroreceptor-HR reflex activity was also markedly impaired after KYN, suggesting functional diminution of sympathetic outflow at the level of the spinal cord after blockade of EAA receptors by KYN. Xanthurenate, a metabolite of KYN without EAA antagonistic properties, produced negligible effects at the same dose of KYN. While these findings do not identify the putative EAA pathway, they do provide the first demonstration that this system is tonically active in conscious rats.
Internal ID Number: 2402340
URI: http://ahro.austin.org.au/austinjspui/handle/1/11869
URL: http://www.ncbi.nlm.nih.gov/pubmed/2402340
Type: Journal Article
Subjects: Animals
Blood Pressure.drug effects
Female
Heart Rate.drug effects
Kynurenic Acid.pharmacology
Male
Pressoreceptors.physiology
Rats
Reflex.drug effects
Appears in Collections:Journal articles

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