Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/11860
Title: Meta-analysis of pre-clinical studies of early decompression in acute spinal cord injury: a battle of time and pressure.
Authors: Batchelor, Peter Egerton;Wills, Taryn E;Skeers, Peta;Battistuzzo, Camila R;Macleod, Malcolm R;Howells, David William;Sena, Emily S
Affiliation: Florey Institute of Neuroscience and Mental Health, Heidelberg, Victoria, Australia.
Issue Date: 23-Aug-2013
Citation: Plos One 2013; 8(8): e72659
Abstract: The use of early decompression in the management of acute spinal cord injury (SCI) remains contentious despite many pre-clinical studies demonstrating benefits and a small number of supportive clinical studies. Although the pre-clinical literature favours the concept of early decompression, translation is hindered by uncertainties regarding overall treatment efficacy and timing of decompression.We performed meta-analysis to examine the pre-clinical literature on acute decompression of the injured spinal cord. Three databases were utilised; PubMed, ISI Web of Science and Embase. Our inclusion criteria consisted of (i) the reporting of efficacy of decompression at various time intervals (ii) number of animals and (iii) the mean outcome and variance in each group. Random effects meta-analysis was used and the impact of study design characteristics assessed with meta-regression.Overall, decompression improved behavioural outcome by 35.1% (95%CI 27.4-42.8; I(2)=94%, p<0.001). Measures to minimise bias were not routinely reported with blinding associated with a smaller but still significant benefit. Publication bias likely also contributed to an overestimation of efficacy. Meta-regression demonstrated a number of factors affecting outcome, notably compressive pressure and duration (adjusted r(2)=0.204, p<0.002), with increased pressure and longer durations of compression associated with smaller treatment effects. Plotting the compressive pressure against the duration of compression resulting in paraplegia in individual studies revealed a power law relationship; high compressive forces quickly resulted in paraplegia, while low compressive forces accompanying canal narrowing resulted in paresis over many hours.These data suggest early decompression improves neurobehavioural deficits in animal models of SCI. Although much of the literature had limited internal validity, benefit was maintained across high quality studies. The close relationship of compressive pressure to the rate of development of severe neurological injury suggests that pressure local to the site of injury might be a useful parameter determining the urgency of decompression.
Internal ID Number: 24009695
URI: http://ahro.austin.org.au/austinjspui/handle/1/11860
DOI: 10.1371/journal.pone.0072659
URL: http://www.ncbi.nlm.nih.gov/pubmed/24009695
Type: Journal Article
Subjects: Animals
Decompression, Surgical
Disease Models, Animal
Publication Bias
Spinal Cord Injuries.pathology.physiopathology.surgery
Time Factors
Treatment Outcome
Appears in Collections:Journal articles

Files in This Item:
There are no files associated with this item.


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.