Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/11858
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dc.contributor.authorCasey, S P-
dc.contributor.authorLokan, Julie-
dc.contributor.authorTestro, Adam G-
dc.contributor.authorFarquharson, Shawna-
dc.contributor.authorConnelly, A-
dc.contributor.authorProietto, Joseph-
dc.contributor.authorAngus, Peter W-
dc.date.accessioned2015-05-16T01:29:17Z
dc.date.available2015-05-16T01:29:17Z
dc.date.issued2013-09-05-
dc.identifier.citationAmerican Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2013; 13(11): 3031-4en_US
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/11858en
dc.description.abstractWe describe the first case of a patient undergoing orthoptic liver transplantation for acquired generalized lipodystrophy-related nonalcoholic steatohepatitis who developed severe recurrence of nonalcoholic fatty liver disease in the first few months posttransplant but responded rapidly to the administration of exogenous leptin. The beneficial effects of therapy were supported by histology along with magnetic resonance spectroscopy studies, which demonstrated that leptin therapy greatly reduced fat deposition in the liver. Leptin therapy may have a role to play in preventing patients with lipodystrophy developing end-stage liver disease or in rescuing such patients who develop disease recurrence postliver transplantation.en_US
dc.language.isoenen
dc.subject.otherLeptinen
dc.subject.otherlipodystrophyen
dc.subject.otherliver transplantationen
dc.subject.othernonalcoholic steatohepatitisen
dc.subject.otherAdulten
dc.subject.otherFatty Liver.complications.pathology.surgeryen
dc.subject.otherFemaleen
dc.subject.otherHumansen
dc.subject.otherLeptin.pharmacologyen
dc.subject.otherLipodystrophy.complications.pathology.surgeryen
dc.subject.otherLiver Transplantation.adverse effectsen
dc.subject.otherMagnetic Resonance Spectroscopyen
dc.subject.otherNon-alcoholic Fatty Liver Diseaseen
dc.subject.otherPostoperative Complications.prevention & controlen
dc.subject.otherSecondary Preventionen
dc.subject.otherTreatment Outcomeen
dc.titlePost-liver transplant leptin results in resolution of severe recurrence of lipodystrophy-associated nonalcoholic steatohepatitis.en_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleAmerican Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeonsen_US
dc.identifier.affiliationVictorian Liver Transplant Uniten_US
dc.identifier.doi10.1111/ajt.12436en_US
dc.description.pages3031-4en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/24007548en
dc.type.contentTexten_US
dc.type.austinJournal Articleen
local.name.researcherAngus, Peter W
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptGastroenterology and Hepatology-
crisitem.author.deptVictorian Liver Transplant Unit-
crisitem.author.deptGastroenterology and Hepatology-
crisitem.author.deptThe Florey Institute of Neuroscience and Mental Health-
crisitem.author.deptMedicine (University of Melbourne)-
crisitem.author.deptVictorian Liver Transplant Unit-
crisitem.author.deptGastroenterology and Hepatology-
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