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dc.contributor.authorCarney, Patrick Wen
dc.contributor.authorMasterton, Richard A Jen
dc.contributor.authorGill, Deepak Sen
dc.contributor.authorJackson, Graeme Den
dc.date.accessioned2015-05-16T01:29:09Z
dc.date.available2015-05-16T01:29:09Z
dc.date.issued2013-08-06en
dc.identifier.citationEpilepsy Research 2013; 106(3): 451-5en
dc.identifier.govdoc23992952en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/11856en
dc.description.abstractIn this study we used EEG-fMRI to investigate whether peri-ventricular nodular heterotopia (PNH) are connected to the seizure generating network in individuals initially diagnosed with absence seizures (AS) who were later found to have co-existent PNH. We performed event related EEG-fMRI of the patients typical events as well as performing functional connectivity (FC) seeded from the PNH to answer this question. Both subjects demonstrated event related BOLD change in the "core" absence network. Subject 1 also displayed event related BOLD increase in the nodules while FC analysis demonstrated connectivity between the nodules and the thalami and striatum bilaterally. The second subject did not display event related BOLD in the PNH but FC analysis demonstrated strong connections between the PNH and the parietal cortex. This study demonstrates that the peri-ventricular nodules can show connectivity to the absence network in individuals with AS and may be involved in seizure generation.en
dc.language.isoenen
dc.subject.otherAbsence seizuresen
dc.subject.otherEEGen
dc.subject.otherFunctional neuroimagingen
dc.subject.otherNodular heterotopiaen
dc.subject.otherfMRIen
dc.subject.otherChilden
dc.subject.otherCohort Studiesen
dc.subject.otherElectroencephalographyen
dc.subject.otherEpilepsy, Absence.complications.pathologyen
dc.subject.otherEpilepsy, Generalized.complications.pathologyen
dc.subject.otherEvoked Potentialsen
dc.subject.otherHumansen
dc.subject.otherImage Processing, Computer-Assisteden
dc.subject.otherMagnetic Resonance Imagingen
dc.subject.otherMaleen
dc.subject.otherMyoclonic Epilepsy, Juvenile.complications.pathologyen
dc.subject.otherNeostriatum.pathologyen
dc.subject.otherParietal Lobe.pathologyen
dc.subject.otherPeriventricular Nodular Heterotopia.complications.pathologyen
dc.subject.otherSeizures.complications.pathologyen
dc.subject.otherThalamus.pathologyen
dc.subject.otherYoung Adulten
dc.titleNodular heterotopia and absence seizures: fMRI evidence that they may be connected.en
dc.typeJournal Articleen
dc.identifier.journaltitleEpilepsy researchen
dc.identifier.affiliationAustin Health, Heidelberg, Victoria 3081, Australiaen
dc.identifier.affiliationEpilepsy Research Centre, Department of Medicine, University of Melbourne, Heidelberg, Victoria 3084, Australiaen
dc.identifier.affiliationBrain Research Institute, Florey Institute of Neuroscience and Mental Health, Heidelberg, Victoria 3084, Australiaen
dc.identifier.doi10.1016/j.eplepsyres.2013.07.005en
dc.description.pages451-5en
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pubmed/23992952en
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