Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/11855
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dc.contributor.authorLu, K Jen
dc.contributor.authorKearney, Leighton Gen
dc.contributor.authorOrd, Men
dc.contributor.authorJones, Elizabeth Fen
dc.contributor.authorBurrell, Louise Men
dc.contributor.authorSrivastava, Piyush Men
dc.date.accessioned2015-05-16T01:29:05Z
dc.date.available2015-05-16T01:29:05Z
dc.date.issued2013-08-15en
dc.identifier.citationInternational Journal of Cardiology 2013; 168(6): 5243-8en
dc.identifier.govdoc23978361en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/11855en
dc.description.abstractInfective endocarditis (IE) is associated with high morbidity and mortality. The epidemiology of IE is changing, affecting more elderly patients with increased medical comorbidities. We aimed to assess the ability of the age adjusted Charlson Co-morbidity Index (ACCI) to predict early and late outcomes.Between 1998 and 2010, adult patients with definite IE according to the modified Duke criteria were identified. The primary outcome was in-hospital and all-cause mortality. The secondary outcome was predictors of the primary outcome incorporating ACCI.148 patients with IE were followed up for a mean of 3.8 ± 3 years. The mean age was 57 ± 17 years and 66% were male. In-hospital mortality and all-cause mortality were 24 and 47% respectively. Comorbid conditions included diabetes mellitus (DM) (21%); ischaemic heart disease (16%); heart failure (HF) (14%); renal failure (eGFR <60 ml/min/1.73 m(2)) (19%); and anaemia (64%). The most common causative organism was Staphylococcus aureus (53%). ACCI was >3 in 59% of patients. Cardiac surgery was performed in 45% of patients. On Cox regression analysis, ACCI >3 (HR=3.0 [1.5-6.0], p<0.002), new onset HF (HR=2.2 [1.3-3.6], p<0.003), anaemia (HR=1.8 [1.1-3.2], p=0.04) and age-per decade (HR=1.4 [1.1-1.7]. p=0.004) were independently associated with all-cause mortality. ACCI >3 was the strongest predictor of in-hospital mortality (OR=8.4 [2.8-24], p<0.001). Of the individual ACCI components, prior HF, DM with complications and metastatic disease were independent predictors of all-cause mortality.In-hospital and all-cause mortality of IE remain high. An ACCI >3 was a strong predictor of mortality, in addition to age, new HF and anaemia.en
dc.language.isoenen
dc.subject.otherCharlson Co-morbidity Indexen
dc.subject.otherInfective endocarditisen
dc.subject.otherMortalityen
dc.subject.otherAdulten
dc.subject.otherAge Distributionen
dc.subject.otherAgeden
dc.subject.otherAnemia.mortalityen
dc.subject.otherComorbidityen
dc.subject.otherEndocarditis, Bacterial.mortalityen
dc.subject.otherFemaleen
dc.subject.otherFollow-Up Studiesen
dc.subject.otherHeart Failure.mortalityen
dc.subject.otherHospital Mortalityen
dc.subject.otherHumansen
dc.subject.otherKaplan-Meier Estimateen
dc.subject.otherMaleen
dc.subject.otherMiddle Ageden
dc.subject.otherPredictive Value of Testsen
dc.subject.otherPrevalenceen
dc.subject.otherProportional Hazards Modelsen
dc.subject.otherRetrospective Studiesen
dc.subject.otherRisk Factorsen
dc.subject.otherStaphylococcal Infections.mortalityen
dc.subject.otherStreptococcal Infections.mortalityen
dc.titleAge adjusted Charlson Co-morbidity Index is an independent predictor of mortality over long-term follow-up in infective endocarditis.en
dc.typeJournal Articleen
dc.identifier.journaltitleInternational journal of cardiologyen
dc.identifier.affiliationDepartment of Medicine, University of Melbourne and Austin Health, Victoria, Australiaen
dc.identifier.affiliationDepartment of Cardiology, Austin Health, Victoria, Australiaen
dc.identifier.doi10.1016/j.ijcard.2013.08.023en
dc.description.pages5243-8en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/23978361en
dc.type.austinJournal Articleen
local.name.researcherBurrell, Louise M
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptCardiology-
crisitem.author.deptCardiology-
crisitem.author.deptCardiology-
crisitem.author.deptGeneral Medicine-
crisitem.author.deptMedicine (University of Melbourne)-
crisitem.author.deptMedicine (University of Melbourne)-
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