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|Title:||Community-onset Staphylococcus aureus infections presenting to general practices in South-eastern Australia.|
|Authors:||Bennett, Catherine M;Coombs, Geoffrey W;Wood, G M;Howden, Benjamin P;Johnson, L E A;White, D;Johnson, Paul D R|
|Affiliation:||The University of Melbourne, Melbourne, Australia.|
Department of Microbiology and Infectious Diseases, PathWest Laboratory Medicine-WA, Royal Perth Hospital, Australia.
Austin Health, Melbourne, Australia.
|Citation:||Epidemiology and Infection 2013; 142(3): 501-11|
|Abstract:||Community-acquired Staphylococcus aureus infections are a public health concern, yet little is known about infections that do not present to hospital. We identified community-onset S. aureus infections via specimens submitted to a community-based pathology service. Referring doctors confirmed eligibility and described infection site, severity and treatment. Isolates were characterized on antibiotic resistance, PFGE, MLST/SCCmec, and Panton-Valentine leukocidin (PVL), representing 106 community-onset infections; 34 non-multiresistant methicillin-resistant S. aureus (nmMRSA) (resistant to <3 non-β-lactam antibiotics), 15 multiply antibiotic-resistant MRSA (mMRSA) and 57 methicillin-sensitive S. aureus (MSSA). Most (93%) were skin and soft tissue infections. PVL genes were carried by 42% of nmMRSA isolates [95% confidence interval (CI) 26-61] and 15% of MSSA (95% CI 8-28). PVL was associated with infections of the trunk, head or neck (56·4% vs. 24·3%, P=0·005) in younger patients (23 vs. 52 years, P<0·001), and with boils or abscesses (OR 8·67, 95% CI 2·9-26·2), suggesting underlying differences in exposure and/or pathogenesis.|
|Internal ID Number:||23866772|
Community-Acquired Infections.drug therapy.epidemiology.microbiology
Drug Resistance, Bacterial
Methicillin-Resistant Staphylococcus aureus.isolation & purification.pathogenicity
Polymerase Chain Reaction
Severity of Illness Index
Staphylococcal Infections.drug therapy.epidemiology.microbiology
Staphylococcus aureus.isolation & purification.pathogenicity
|Appears in Collections:||Journal articles|
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