Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/11781
Title: Electronic estimations of renal function are inaccurate in solid-organ transplant recipients and can result in significant underdosing of prophylactic valganciclovir.
Authors: Trevillyan, J;Angus, Peter W;Shelton, E;Whitlam, J;Ierino, F;Pavlovic, J;Gregory, D;Urbancic, K;Torresi, Joseph;Testro, Adam G;Grayson, M Lindsay
Affiliation: Austin Health, Heidelberg, Victoria, Australia. Janine.trevillyan@monash.edu
Issue Date: 3-Jun-2013
Citation: Antimicrobial Agents and Chemotherapy 2013; 57(8): 4058-60
Abstract: In a prospective study of solid-organ transplant recipients (n = 22; 15 hepatic and 7 renal) receiving valganciclovir for cytomegalovirus (CMV) prophylaxis, electronic estimation of glomerular filtration rate (eGFR) underestimated the true GFR (24-h urine creatinine clearance) by >20% in 14/22 (63.6%). Its use was associated with inappropriate underdosing of valganciclovir, while the Cockroft-Gault equation was accurate in 21/22 patients (95.4%). Subtherapeutic ganciclovir levels (≤ 0.6 mg/liter) were common, occurring in 10/22 patients (45.4%); 7 had severely deficient levels (<0.3 mg/liter).
Internal ID Number: 23733466
URI: http://ahro.austin.org.au/austinjspui/handle/1/11781
DOI: 10.1128/AAC.00375-13
URL: http://www.ncbi.nlm.nih.gov/pubmed/23733466
Type: Journal Article
Subjects: Adult
Antiviral Agents.administration & dosage.therapeutic use
Automatic Data Processing
Creatine.urine
Cytomegalovirus.isolation & purification
Cytomegalovirus Infections.drug therapy
Female
Ganciclovir.administration & dosage.analogs & derivatives.therapeutic use
Glomerular Filtration Rate
Humans
Kidney Transplantation
Liver Transplantation
Male
Middle Aged
Predictive Value of Tests
Prospective Studies
Reproducibility of Results
Appears in Collections:Journal articles

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