Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/11773
Full metadata record
DC FieldValueLanguage
dc.contributor.authorFam, Barbara Cen
dc.contributor.authorJoannides, Christos Nen
dc.contributor.authorAndrikopoulos, Sofianosen
dc.date.accessioned2015-05-16T01:24:03Z
dc.date.available2015-05-16T01:24:03Z
dc.date.issued2012-10-01en
dc.identifier.citationAdipocyte; 1(4): 259-264en
dc.identifier.govdoc23700543en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/11773en
dc.description.abstractLiver fructose-1,6-bisphosphatase (FBPase) is a regulatory enzyme in gluconeogenesis that is elevated by obesity and dietary fat intake. Whether FBPase functions only in glucose metabolism or has other metabolic roles is currently unclear. In our recently published study, we examined the importance of liver FBPase in body weight regulation by performing a series of comprehensive physiological and biochemical assessments of energy balance and specific intervention studies in our transgenic mouse line that overexpresses FBPase specifically in the liver. Compared with negative littermates, these FBPase transgenic mice weighed 10% less, had 50% less adiposity, ate 15% less food but did not have altered energy expenditure. Increased circulating leptin and cholecystokinin levels, elevated fatty acid oxidation and reduced appetite stimulating neuropeptides, neuropeptide Y (NPY) and agouti-related peptide (AGRP), underpinned this phenotype. Blocking the action of FBPase returned food intake and body weight to those of the negative littermates. Our study is the first to identify liver FBPase as a previously unknown regulator of appetite and adiposity. Importantly, this work recognizes the liver as an important organ in appetite and body weight regulation. This commentary will provide further insight and expand on this novel concept that the liver does in fact play an important role in adiposity.en
dc.language.isoenen
dc.subject.other3-beta-hydroxybutyrateen
dc.subject.otherCCKen
dc.subject.otherFBPase transgenic miceen
dc.subject.otherNZO mouseen
dc.subject.otheradiposityen
dc.subject.otherappetiteen
dc.subject.otherbody weight regulationen
dc.subject.otherleptinen
dc.subject.otherliveren
dc.subject.othervagus nerveen
dc.titleThe liver: Key in regulating appetite and body weight.en
dc.typeJournal Articleen
dc.identifier.journaltitleAdipocyteen
dc.identifier.affiliationDepartment of Medicine (Austin Health); University of Melbourne; Heidelberg, VIC Australiaen
dc.identifier.doi10.4161/adip.21448en
dc.description.pages259-264en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/23700543en
dc.type.austinJournal Articleen
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
Appears in Collections:Journal articles
Show simple item record

Page view(s)

6
checked on Mar 28, 2024

Google ScholarTM

Check


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.