Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/11760
Title: In vitro autoradiographic localization of binding to angiotensin receptors in the rat heart.
Authors: Allen, A M;Yamada, H;Mendelsohn, Frederick AO
Affiliation: Department of Medicine, University of Melbourne, Austin Hospital, Heidelberg, Victoria, Australia.
Issue Date: 1-Jul-1990
Citation: International Journal of Cardiology; 28(1): 25-33
Abstract: The distribution of binding to angiotensin II receptors in the rat heart was determined by quantitative in vitro autoradiography employing 125I-[Sar1, Ile8] angiotensin II as the radioligand. Low density binding occurs in the myocardium of both the atriums and ventricles and in the media of the aorta, pulmonary arteries and superior caval vein. Dense punctate binding is found over parasympathetic nerve bundles and some cells of the intracardiac ganglions. Binding is very low in nerves which do not stain for acetylcholinesterase. A moderate to high density of binding sites occurs throughout the conduction system, including the sinus node (low), the atrioventricular node (high) and the atrioventricular bundle (moderate). An extremely high density of binding is observed over the remnant of the arterial duct. These findings demonstrate many sites at which angiotensin II could exert its cardiac actions, including anatomical evidence supporting an action on cardiac myocytes, terminals of the vagal nerves, parasympathetic ganglion cells, and the conduction system.
Internal ID Number: 2365529
URI: http://ahro.austin.org.au/austinjspui/handle/1/11760
URL: http://www.ncbi.nlm.nih.gov/pubmed/2365529
Type: Journal Article
Subjects: Angiotensin II.metabolism
Animals
Autonomic Nervous System.metabolism
Autoradiography
Binding Sites
Heart.innervation
In Vitro Techniques
Iodine Radioisotopes
Male
Myocardium.metabolism
Radioligand Assay
Rats
Rats, Inbred Strains
Receptors, Angiotensin.metabolism
Appears in Collections:Journal articles

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