Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/11753
Title: Population genetics and the evolution of virulence in Staphylococcus aureus.
Authors: Chua, Kyra Y L;Howden, Benjamin P;Jiang, Jhih-Hang;Stinear, Timothy P;Peleg, Anton Y
Affiliation: Department of Microbiology and Immunology, University of Melbourne, Victoria 3052, Australia; Austin Centre for Infection Research (ACIR), Infectious Diseases Department, Austin Health, Heidelberg, Victoria 3084, Australia; Microbiology Department, Austin Health, Heidelberg, Victoria 3084, Australia.
Department of Microbiology and Immunology, University of Melbourne, Victoria 3052, Australia; Department of Microbiology, Monash University, Clayton, Victoria 3800, Australia; Austin Centre for Infection Research (ACIR), Infectious Diseases Department, Austin Health, Heidelberg, Victoria 3084, Australia; Microbiology Department, Austin Health, Heidelberg, Victoria 3084, Australia.
Department of Microbiology, Monash University, Clayton, Victoria 3800, Australia.
Department of Microbiology and Immunology, University of Melbourne, Victoria 3052, Australia.
Department of Microbiology, Monash University, Clayton, Victoria 3800, Australia; Department of Infectious Diseases, The Alfred Hospital, Melbourne, Victoria 3181, Australia; Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Boston, MA, USA. Electronic address: anton.peleg@monash.edu.
Issue Date: 27-Apr-2013
Citation: Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases 2013; 21(): 554-62
Abstract: Staphylococcus aureus is one of the most important human pathogens, causing life-threatening infection in the community and hospital setting. The population genetics of S. aureus and the evolution of virulence is the focus of this review. We describe the various techniques in determining S. aureus population structure and discuss the insights gained from whole genome sequencing of various S. aureus strains. The emergence of community-acquired, methicillin-resistant S. aureus provides a framework for the discussion on evolution of virulence, and the role of horizontal gene transfer in the development of virulence and antibiotic resistance is explored. The knowledge generated from population genetics has the potential to inform strategies to assist in the prevention or treatment of this highly successful human pathogen.
Internal ID Number: 23628638
URI: http://ahro.austin.org.au/austinjspui/handle/1/11753
DOI: 10.1016/j.meegid.2013.04.026
URL: http://www.ncbi.nlm.nih.gov/pubmed/23628638
Type: Journal Article
Subjects: Methicillin-resistant S. aureus
Molecular epidemiology
Multi-locus sequence typing
S. aureus
Drug Resistance, Bacterial
Evolution, Molecular
Gene Transfer, Horizontal
Genome, Bacterial
Humans
Molecular Typing
Sequence Analysis, DNA
Staphylococcal Infections.microbiology
Staphylococcus aureus.classification.genetics.isolation & purification.pathogenicity
Virulence Factors.genetics.metabolism
Appears in Collections:Journal articles

Files in This Item:
There are no files associated with this item.


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.