Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/11744
Title: Cognitive changes after saline or plasmalyte infusion in healthy volunteers: a multiple blinded, randomized, cross-over trial.
Authors: Story, David A;Lees, Lucy;Weinberg, Laurence;Teoh, Soon-Yee;Lee, Katherine J;Velissaris, Sarah;Bellomo, Rinaldo;Wilson, Sarah J
Affiliation: Perioperative and Pain Medicine Unit, Melbourne Medical School, The University of Melbourne, Melbourne, Victoria 3010, Australia. david.story@austin.org.au
Issue Date: 1-Sep-2013
Citation: Anesthesiology; 119(3): 569-75
Abstract: In an incidental finding, during a study of plasma chemistry after crystalloid infusion, participants reported subjective cognitive changes, particularly slower thinking, after saline but not Hartmann's (Ringer's lactate) solution. The authors tested the hypothesis that saline infusion would produce greater adverse cognitive changes than Plasmalyte infusion.The authors conducted a randomized, cross-over, multiple blinded study of healthy adult volunteers. On separate days, participants received 30 ml/kg over 1 h of either 0.9% saline or Plasmalyte with the order randomly allocated. Plasma chemistry was tested on venous samples. As part of a battery of cognitive tests our primary endpoint was the reaction time index after infusion.The authors studied 25 participants. Plasma chloride was greater after saline than after Plasmalyte: mean difference 5.4 mM (95% CI, 4.1-6.6 mM; P < 0.001). Saline was also associated with greater metabolic acidosis: base-excess 2.5 mM more negative (95% CI, 1.9-3.0 mM more negative; P < 0.001). There was no evidence of a difference in the reaction time index between the two interventions: mean reaction time index 394 ms (SD, 72) after saline versus 385 ms (SD, 55) after Plasmalyte. Difference: saline 9 ms slower (95% CI, 30 ms slower to 12 ms faster; P = 0.39). There were minimal differences in the other cognitive and mood tests.Despite expected differences in plasma chemistry, the authors found that measures of cognition did not differ after infusions of Plasmalyte or saline.
Internal ID Number: 23598288
URI: http://ahro.austin.org.au/austinjspui/handle/1/11744
DOI: 10.1097/ALN.0b013e31829416ba
URL: http://www.ncbi.nlm.nih.gov/pubmed/23598288
Type: Journal Article
Subjects: Acidosis.chemically induced
Adult
Cognition.drug effects
Cross-Over Studies
Female
Gluconates.adverse effects
Humans
Magnesium Chloride.adverse effects
Male
Middle Aged
Potassium Chloride.adverse effects
Reaction Time.drug effects
Sodium Acetate.adverse effects
Sodium Chloride.adverse effects
Appears in Collections:Journal articles

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