Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/11738
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dc.contributor.authorMasterton, Richard A Jen
dc.contributor.authorCarney, Patrick Wen
dc.contributor.authorAbbott, David Fen
dc.contributor.authorJackson, Graeme Den
dc.date.accessioned2015-05-16T01:21:52Z
dc.date.available2015-05-16T01:21:52Z
dc.date.issued2013-04-15en
dc.identifier.citationEpilepsia 2013; 54(5): 801-8en
dc.identifier.govdoc23586661en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/11738en
dc.description.abstractThe aim of this study was to provide better spatiotemporal description of the brain activity observed during generalized spike-and-wave (GSW) discharges. Simultaneous electroencephalography and functional magnetic resonance imaging (EEG-fMRI) studies of these epileptiform events have shown regional differences in the timing of fMRI signal changes, which suggests activities within multiple interacting networks rather than a single unified network.EEG-fMRI recordings from eight patients with childhood absence epilepsy (CAE) were studied using event-related independent components analysis (eICA). This technique separates the fMRI signal changes observed during GSW discharges into different spatial components, each showing different event-related timing. Unlike standard independent components analysis (ICA), which is applied to the entire fMRI time series, the eICA method is applied only to the event-related time courses at each voxel, which means that only a small number of components are generated that are all explicitly related to the event of interest.Six eICA components were identified, representing distinct GSW-related subnetworks. Activations were detected in a number of brain regions, including the striatum, which have not previously been reported in association with GSW in CAE patients.The eICA results support previous findings that the earliest activity associated with GSW may be in posterior cortical regions and provide new evidence that the thalamostriate network may play a more important role in the generation of GSW than suggested by previous studies.en
dc.language.isoenen
dc.subject.otherBrain.blood supply.pathology.physiopathologyen
dc.subject.otherBrain Mappingen
dc.subject.otherChilden
dc.subject.otherChild, Preschoolen
dc.subject.otherElectroencephalographyen
dc.subject.otherEpilepsy, Absence.pathology.physiopathologyen
dc.subject.otherFemaleen
dc.subject.otherHumansen
dc.subject.otherImage Processing, Computer-Assisteden
dc.subject.otherMagnetic Resonance Imagingen
dc.subject.otherMaleen
dc.subject.otherNeural Pathways.blood supply.pathologyen
dc.subject.otherOxygen.blooden
dc.subject.otherPrincipal Component Analysisen
dc.titleAbsence epilepsy subnetworks revealed by event-related independent components analysis of functional magnetic resonance imaging.en
dc.typeJournal Articleen
dc.identifier.journaltitleEpilepsiaen
dc.identifier.affiliationBrain Research Institute, Florey Institute of Neuroscience and Mental Health, Austin Hospital, Heidelberg, Victoria, Australiaen
dc.identifier.doi10.1111/epi.12163en
dc.description.pages801-8en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/23586661en
dc.type.austinJournal Articleen
local.name.researcherAbbott, David F
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptNeurology-
crisitem.author.deptThe Florey Institute of Neuroscience and Mental Health-
crisitem.author.deptNeurology-
crisitem.author.deptThe Florey Institute of Neuroscience and Mental Health-
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