Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/11734
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dc.contributor.authorRowe, Christopher C-
dc.contributor.authorPejoska, Svetlana-
dc.contributor.authorMulligan, Rachel S-
dc.contributor.authorJones, Gareth-
dc.contributor.authorChan, J Gordon-
dc.contributor.authorSvensson, Samuel-
dc.contributor.authorCselényi, Zsolt-
dc.contributor.authorMasters, Colin L-
dc.contributor.authorVillemagne, Victor L-
dc.date.accessioned2015-05-16T01:21:36Z-
dc.date.available2015-05-16T01:21:36Z-
dc.date.issued2013-04-10-
dc.identifier.citationJournal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine 2013; 54(6): 880-6en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/11734en
dc.description.abstract(11)C-Pittsburgh compound-B ((11)C-PiB) is the benchmark radiotracer for imaging of β-amyloid (Aβ) plaque in Alzheimer disease (AD). (18)F-labeled Aβ tracers subsequently developed for clinical use show higher nonspecific white matter binding and, in some cases, lower cortical binding in AD that could lead to less accurate interpretation of scans. We compared the cortical and white matter binding of a new (18)F-labeled Aβ tracer, (18)F-AZD4694 (recently renamed NAV4694), with (11)C-PiB in the same subjects.Forty-five participants underwent PET imaging with (11)C-PiB and (18)F-AZD4694 (25 healthy elderly controls [HCs], 10 subjects with mild cognitive impairment, 7 subjects with probable AD, and 3 subjects with probable frontotemporal dementia). Images were coregistered so that region-of-interest placement was identical on both scans, and standardized uptake value ratios (SUVRs) using the cerebellar cortex as a reference region were calculated between 40 and 70 min after injection for both tracers.(18)F-AZD4694 showed reversible binding kinetics similar to (11)C-PiB, reaching an apparent steady state at 50 min after injection. Both radiotracers showed a similar dynamic range of neocortical SUVR (1.1-3.3 and 1.0-3.2 SUVR for (11)C-PiB and (18)F-AZD4694, respectively) and identical low nonspecific white matter binding, with frontal cortex-to-white matter ratios of 0.7 ± 0.2 and 1.3 ± 0.2 for both radiotracers in HCs and AD subjects, respectively. There was an excellent linear correlation between (11)C-PiB and (18)F-AZD4694 neocortical SUVR (slope of 0.95, r = 0.99, P < 0.0001).(18)F-AZD4694 displays imaging characteristics nearly identical to those of (11)C-PiB. The low white matter and high cortical binding in AD indicate that this tracer is well suited to both clinical and research use.en
dc.language.isoenen
dc.subject.otherAlzheimer’s diseaseen
dc.subject.otheren
dc.subject.otheramyloid imagingen
dc.subject.otherpositron emission tomographyen
dc.subject.otherAgeden
dc.subject.otherAging.metabolismen
dc.subject.otherAmyloid beta-Peptides.metabolismen
dc.subject.otherBenzofurans.diagnostic use.metabolismen
dc.subject.otherBenzothiazoles.diagnostic use.metabolismen
dc.subject.otherBrain.metabolism.radionuclide imagingen
dc.subject.otherDementia.metabolism.radionuclide imagingen
dc.subject.otherFemaleen
dc.subject.otherHumansen
dc.subject.otherHydrocarbons, Fluorinated.diagnostic use.metabolismen
dc.subject.otherMaleen
dc.subject.otherMolecular Imaging.methodsen
dc.subject.otherPositron-Emission Tomographyen
dc.titleHead-to-head comparison of 11C-PiB and 18F-AZD4694 (NAV4694) for β-amyloid imaging in aging and dementia.en
dc.typeJournal Articleen
dc.identifier.journaltitleJournal of Nuclear Medicineen
dc.identifier.affiliationDepartment of Nuclear Medicine and Centre for PET, Austin Health, Heidelberg, Victoria, Australiaen
dc.identifier.doi10.2967/jnumed.112.114785en
dc.description.pages880-6en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/23575995en
dc.type.contentTexten
dc.type.austinJournal Articleen
local.name.researcherChan, J Gordon
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptMolecular Imaging and Therapy-
crisitem.author.deptMolecular Imaging and Therapy-
crisitem.author.deptMolecular Imaging and Therapy-
crisitem.author.deptThe Florey Institute of Neuroscience and Mental Health-
crisitem.author.deptMolecular Imaging and Therapy-
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