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Title: | The role of natural killer cells in hepatitis C infection. | Austin Authors: | Howell, Jessica;Visvanathan, Kumar | Affiliation: | Liver Transplant Unit, Austin Hospital, Melbourne, Australia | Issue Date: | 4-Apr-2013 | Publication information: | Antiviral Therapy 2013; 18(7): 853-65 | Abstract: | HCV infection is an exponentially growing health burden worldwide, with an estimated 170 million people infected. Although therapies for HCV are continually improving, there remain a considerable proportion of patients who do not achieve viral eradication and develop liver disease. Natural killer (NK) cells are crucial for T-cell activation and are one of the first-line sentinel cell responders to viral infection. A recent explosion in studies exploring the role of NK cells in HCV infection has yielded important mechanistic information and intriguing potential therapeutic options for HCV infection. This review provides a general overview of normal NK cell function and outlines some of the important mechanisms characterizing the immune interplay between NK cells and HCV infection. | Gov't Doc #: | 23559549 | URI: | https://ahro.austin.org.au/austinjspui/handle/1/11725 | DOI: | 10.3851/IMP2565 | Journal: | Antiviral therapy | URL: | https://pubmed.ncbi.nlm.nih.gov/23559549 | Type: | Journal Article | Subjects: | Adaptive Immunity Hepacivirus.immunology Hepatitis C.complications.immunology.metabolism Hepatitis C, Chronic Humans Immunity, Innate Killer Cells, Natural.immunology.metabolism Liver.immunology.pathology Liver Cirrhosis.etiology Lymphocyte Activation.immunology Natural Killer T-Cells.immunology.metabolism Receptors, Natural Killer Cell.metabolism Receptors, Pattern Recognition.metabolism |
Appears in Collections: | Journal articles |
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