Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/11681
Title: Toll-like receptors in hepatitis C infection: implications for pathogenesis and treatment.
Authors: Howell, Jessica;Angus, Peter W;Gow, Paul J;Visvanathan, Kumar
Affiliation: Liver Transplant Unit, Austin Hospital, Victoria, Australia. Jess.Howell@austin.org.au
Issue Date: 1-May-2013
Citation: Journal of Gastroenterology and Hepatology; 28(5): 766-76
Abstract: Hepatitis C virus (HCV) infection is a significant global health problem, affecting over 150 million people worldwide. While the critical role of the adaptive immune system in HCV infection is well-established, the importance of the innate immune system in HCV infection has only been recognized in more recent years. Toll-like receptors form the cornerstone of the innate immune response, and there is considerable evidence for their crucial role in hepatitis C infection. This review outlines recent advances made in our understanding of the role of Toll-like receptor function in HCV infection, exploring how HCV manipulates host immunity to evade immune clearance and establish persistent infection despite leading to inflammatory hepatic damage.
Internal ID Number: 23432473
URI: http://ahro.austin.org.au/austinjspui/handle/1/11681
DOI: 10.1111/jgh.12170
URL: http://www.ncbi.nlm.nih.gov/pubmed/23432473
Type: Journal Article
Subjects: Adaptive Immunity.immunology
Chemokines.metabolism
Cytokines.metabolism
Dendritic Cells.immunology
Hepatitis C.immunology.therapy
Humans
Immunity, Innate.immunology
Inflammation Mediators.metabolism
Ligands
Liver.immunology
Molecular Targeted Therapy
Signal Transduction.immunology
Toll-Like Receptors.chemistry.immunology.physiology
Appears in Collections:Journal articles

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