Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/11674
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dc.contributor.authorLayton, G Jen
dc.contributor.authorAllen, Terri Jen
dc.contributor.authorJerums, Georgeen
dc.date.accessioned2015-05-16T01:17:30Z
dc.date.available2015-05-16T01:17:30Z
dc.date.issued1990-03-01en
dc.identifier.citationDiabetes Research and Clinical Practice; 8(3): 221-6en
dc.identifier.govdoc2340793en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/11674en
dc.description.abstractThis study has examined glycation of serum albumin and its role in evolving diabetic proteinuria. Renal clearances of endogenous glycated and nonglycated albumin were studied in groups of normal and streptozotocin-induced diabetic Wistar-Kyoto rats over a 32 week period. Concentrations of glycated and nonglycated albumin in serum and urine were measured by rat albumin radioimmunoassay following separation on m-aminophenylboronate affinity columns. Levels of glycated serum albumin in diabetic rats were significantly higher than in normal rats (5.9 +/- 0.7% vs 4.4 +/- 0.3%, P less than 0.05). Median total urinary albumin excretion increased from 120 micrograms/24 h at baseline to 879 micrograms/24 h (P less than 0.05) 28-32 weeks after induction of diabetes. The renal clearance of glycated albumin was approximately twice as great as that of nonglycated albumin in both normal (P less than 0.01) and diabetic (P less than 0.01) rats. However, the glycated albumin/nonglycated albumin clearance ratio in diabetic rats did not correlate with duration of diabetes or with the level of albuminuria. These results indicate that glycation of albumin does not contribute disproportionately to the development of proteinuria in the diabetic rat, during which median renal albumin clearance increased 7-fold. Other factors, such as glycation of the glomerular filtration surface, may have a more important role in the pathogenesis of proteinuria in experimental diabetes.en
dc.language.isoenen
dc.subject.otherAnimalsen
dc.subject.otherDiabetes Mellitus, Experimental.physiopathologyen
dc.subject.otherGlycosuriaen
dc.subject.otherGlycosylationen
dc.subject.otherKidney.physiopathologyen
dc.subject.otherMaleen
dc.subject.otherRatsen
dc.subject.otherRats, Inbred WKYen
dc.subject.otherReference Valuesen
dc.subject.otherSerum Albumin.analysisen
dc.titleLongitudinal evaluation of the renal clearance of glycated albumin in the diabetic rat.en
dc.typeJournal Articleen
dc.identifier.journaltitleDiabetes research and clinical practiceen
dc.identifier.affiliationDepartment of Medicine, University of Melbourne, Austin Hospital, Heidelberg, Victoria, Australiaen
dc.description.pages221-6en
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pubmed/2340793en
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