Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/11668
Title: Influence of food on the bioavailability of a sustained-release verapamil preparation.
Authors: Conway, Elizabeth L;Phillips, P A;Drummer, Olaf H;Louis, William J
Affiliation: University of Melbourne, Department of Medicine, Austin Hospital, Heidelberg, Victoria, Australia.
Issue Date: 1-Mar-1990
Citation: Journal of Pharmaceutical Sciences; 79(3): 228-31
Abstract: The effects of food on the bioavailability of a sustained-release (SR) formulation of verapamil (SR-verapamil; Isoptin SR) were determined in an open, three-way single-dose study involving 12 volunteers receiving (in randomized order) the SR preparation (1 X 240 mg) either fasting or with food and a conventional formulation of verapamil (3 X 80 mg) fasting. Compared with the conventional formulation, SR-verapamil had a reduced Cmax, prolonged tmax, and unchanged t1/2, consistent with its SR formulation. The AUC was 80% of the conventional preparation. Concomitant food administration significantly prolonged the tmax of SR-verapamil from 7.3 +/- 3.4 to 11.7 +/- 6.3 h, but had little effect on Cmax, t1/2, or AUC. Similar results were obtained with the metabolite, norverapamil. Food administration also had little effect on the blood pressure and ECG effects of SR-verapamil. Cautions regarding taking this preparation with food therefore appear to be unnecessary.
Internal ID Number: 2338632
URI: http://ahro.austin.org.au/austinjspui/handle/1/11668
URL: http://www.ncbi.nlm.nih.gov/pubmed/2338632
Type: Journal Article
Subjects: Adult
Aged
Biological Availability
Blood Pressure.drug effects
Chromatography, High Pressure Liquid
Delayed-Action Preparations
Electrocardiography
Female
Food
Half-Life
Heart Rate.drug effects
Humans
Male
Middle Aged
Verapamil.administration & dosage.analogs & derivatives.pharmacokinetics.pharmacology
Appears in Collections:Journal articles

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