Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/11652
Title: (18)F-florbetaben Aβ imaging in mild cognitive impairment.
Authors: Ong, Kevin;Villemagne, Victor L;Bahar-Fuchs, Alex;Lamb, Fiona;Chételat, Gaël;Raniga, Parnesh;Mulligan, Rachel S;Salvado, Olivier;Putz, Barbara;Roth, Katrin;Masters, Colin L;Reininger, Cornelia B;Rowe, Christopher C
Affiliation: Department of Nuclear Medicine and Centre for PET, Austin Health, 145 Studley Road, Heidelberg, VIC 3084, Australia.
Department of Nuclear Medicine and Centre for PET, Austin Health, 145 Studley Road, Heidelberg, VIC 3084, Australia ; Department of Medicine, University of Melbourne, Parkville, VIC 3010, Australia ; Mental Health Research Institute, 155 Oak Street, Parkville, VIC 3052, Australia.
Department of Nuclear Medicine and Centre for PET, Austin Health, 145 Studley Road, Heidelberg, VIC 3084, Australia ; Centre for Research on Aging, Health, and Wellbeing, 63 Eggleston Road, The Australian National University, Acton, ACT 2600, Australia.
Department of Nuclear Medicine and Centre for PET, Austin Health, 145 Studley Road, Heidelberg, VIC 3084, Australia ; Mental Health Research Institute, 155 Oak Street, Parkville, VIC 3052, Australia.
CSIRO Preventative Health National Research Flagship, The Australian e-Health Research Centre - BioMedIA, Herston, QLD 4029, Australia.
Mental Health Research Institute, 155 Oak Street, Parkville, VIC 3052, Australia.
Bayer Pharma AG, Müllerstraße 178, 13353 Berlin, Germany.
Department of Nuclear Medicine and Centre for PET, Austin Health, 145 Studley Road, Heidelberg, VIC 3084, Australia ; Department of Medicine, University of Melbourne, Parkville, VIC 3010, Australia.
Issue Date: 16-Jan-2013
Citation: Alzheimer's Research & Therapy 2013; 5(1): 4
Abstract: (18)F-florbetaben and positron emission tomography were used to examine the relationships between β-amyloid (Aβ) deposition, cognition, hippocampal volume, and white matter hyperintensities in mild cognitive impairment (MCI).Forty-five MCI participants were evaluated. A neocortical standardized uptake value ratio threshold ≥ 1.45 was used to discriminate high from low Aβ burden. Correlations were adjusted for age, gender and years of education.High Aβ burden was found in 53% of MCI. Regression analyses showed standardized uptake value ratio (r = -0.51, P = 0.0015) and hippocampal volume (r = 0.60, P = 0.024) both contributing to episodic memory impairment in independent fashion. White matter hyperintensities correlated with nonmemory cognition, and this correlation was particularly associated with Aβ burden.Higher Aβ deposition in MCI is associated with more severe memory impairment and is contributing to early amnestic symptoms independent of hippocampal atrophy.
Internal ID Number: 23324163
URI: http://ahro.austin.org.au/austinjspui/handle/1/11652
DOI: 10.1186/alzrt158
URL: http://www.ncbi.nlm.nih.gov/pubmed/23324163
Type: Journal Article
Appears in Collections:Journal articles

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