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Title: Siblings with refractory occipital epilepsy showing localized network activity on EEG-fMRI.
Authors: Carney, Patrick W;Harvey, A Simon;Berkovic, Samuel F;Jackson, Graeme D;Scheffer, Ingrid E
Affiliation: Epilepsy Research Centre, Austin Health, Department of Medicine, University of Melbourne, Heidelberg, Victoria, Australia
Issue Date: 7-Jan-2013
Citation: Epilepsia 2013; 54(2): e28-32
Abstract: The benign occipital epilepsies of childhood include Panayiotopoulos and Gastaut syndromes; a third syndrome, idiopathic photosensitive occipital epilepsy may also begin in childhood or adolescence. We describe siblings with occipital epilepsy characterized by refractory, frequent, brief visual seizures and normal magnetic resonance imaging (MRI). Electroencephalography (EEG) with functional MRI (fMRI) supports localization of interictal epileptiform activity to the occipital lobes. Our hypothesis is that the siblings share a genetic focal epilepsy arising from a localized occipital network. Although they share many features of Gastaut syndrome, their refractory ongoing seizures in adolescence is unusual and likely due to underlying genetic determinants.
Internal ID Number: 23294395
DOI: 10.1111/epi.12076
Type: Journal Article
Subjects: Adolescent
Anticonvulsants.therapeutic use
Data Interpretation, Statistical
Epilepsies, Partial.genetics.pathology.physiopathology
Epilepsy, Tonic-Clonic.genetics.pathology.physiopathology
Intellectual Disability.pathology
Lennox Gastaut Syndrome
Magnetic Resonance Imaging
Nerve Net.pathology.physiopathology
Occipital Lobe.pathology.physiopathology
Spasms, Infantile.pathology
Appears in Collections:Journal articles

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