Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/11608
Title: Super-resolution track-density imaging of thalamic substructures: comparison with high-resolution anatomical magnetic resonance imaging at 7.0T.
Authors: Calamante, Fernando;Oh, Se-Hong;Tournier, Jacques-Donald;Park, Sung-Yeon;Son, Young-Don;Chung, Jun-Young;Chi, Je-Geun;Jackson, Graeme D;Park, Chan-Woong;Kim, Young-Bo;Connelly, Alan;Cho, Zang-Hee
Affiliation: Department of Medicine, Austin Hospital, University of Melbourne, Melbourne, Victoria, Australia
Brain Research Institute, Florey Neuroscience Institutes, Melbourne, Victoria, Australia
Issue Date: 14-Nov-2012
Citation: Human Brain Mapping 2012; 34(10): 2538-48
Abstract: The thalamus is one of the most important brain structures, with strong connections between subcortical and cortical areas of the brain. Most of the incoming information to the cortex passes through the thalamus. Accurate identification of substructures of the thalamus is therefore of great importance for the understanding of human brain connectivity. Direct visualization of thalamic substructures, however, is not easily achieved with currently available magnetic resonance imaging (MRI), including ultra-high field MRI such as 7.0T, mainly due to the limited contrast between the relevant structures. Recently, improvements in ultra-high field 7.0T MRI have opened the possibility of observing thalamic substructures by well-adjusted high-resolution T1 -weighted imaging. Moreover, the recently developed super-resolution track-density imaging (TDI) technique, based on results from whole-brain fiber-tracking, produces images with sub-millimeter resolution. These two methods enable us to show markedly improved anatomical detail of the substructures of the thalamus, including their detailed locations and directionality. In this study, we demonstrate the role of TDI for the visualization of the substructures of the thalamic nuclei, and relate these images to T1-weighted imaging at 7.0T MRI.
Internal ID Number: 23151892
URI: http://ahro.austin.org.au/austinjspui/handle/1/11608
DOI: 10.1002/hbm.22083
URL: http://www.ncbi.nlm.nih.gov/pubmed/23151892
Type: Journal Article
Subjects: 7.0T MRI
TDI
diffusion weighted imaging
thalamus
thalamus substructures
track-density imaging
Adult
Algorithms
Diffusion Tensor Imaging.methods
Echo-Planar Imaging.methods
Female
Humans
Imaging, Three-Dimensional.methods
Male
Thalamic Nuclei.ultrastructure
Appears in Collections:Journal articles

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