Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/11594
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dc.contributor.authorChua, Horng-Rueyen
dc.contributor.authorBaldwin, Ian Cen
dc.contributor.authorBailey, Michael Jen
dc.contributor.authorSubramaniam, Ashwinen
dc.contributor.authorBellomo, Rinaldoen
dc.date.accessioned2015-05-16T01:12:35Z
dc.date.available2015-05-16T01:12:35Z
dc.date.issued2012-10-24en
dc.identifier.citationJournal of Critical Care 2012; 27(6): 744.e7-15en
dc.identifier.govdoc23102533en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/11594en
dc.description.abstractTo evaluate circuit lifespan (CL) and bleeding risk during continuous renal replacement therapy (CRRT), in combined liver and renal failure.Single-center retrospective analysis of adults with acute liver failure or decompensated cirrhosis who received CRRT, without anticoagulation or with heparinization in intensive care unit.Seventy-one patients with 539 CRRT circuits were evaluated. Median overall CL was 9 (6-16) hours. CL was 12 (7-24) hours in 51 patients never anticoagulated for CRRT. In 20 patients who subsequently received heparinization, CL was 7 (5-11) hours without anticoagulation, which did not improve with systemic or regional heparinization (P = .231), despite higher peri-circuit activated partial thromboplastin time (APTT) and heparin dose. Using multivariate linear regression, patients with higher baseline APTT or serum bilirubin, or who were not mechanically ventilated, had longer CL (P < .05). Additionally, peri-circuit thrombocytopenia (P < .0001) or higher international normalized ratio (P < .05) predicted longer CL. Of 71 patients, 33 had significant bleeding events. Using multivariate logistic regression, patients with higher baseline APTT, vasoactive drug use >24 hours, or thrombocytopenia, had more bleeding complications (P < .05). Decreasing platelet counts (especially <50 × 10(9)/mm(3)) had an incremental effect on CL (P < .0001).CRRT CL is short in patients with liver failure despite apparent coagulopathy. Thrombocytopenia predicts longer CL and bleeding complications.en
dc.language.isoenen
dc.subject.otherAcute Kidney Injury.therapyen
dc.subject.otherAdulten
dc.subject.otherAnticoagulants.administration & dosage.adverse effectsen
dc.subject.otherFemaleen
dc.subject.otherFibrosis.therapyen
dc.subject.otherHemorrhage.etiologyen
dc.subject.otherHeparin.administration & dosage.adverse effectsen
dc.subject.otherHumansen
dc.subject.otherIncidenceen
dc.subject.otherIntensive Care Unitsen
dc.subject.otherLiver Failure, Acute.therapyen
dc.subject.otherMaleen
dc.subject.otherMiddle Ageden
dc.subject.otherPartial Thromboplastin Timeen
dc.subject.otherPlatelet Counten
dc.subject.otherRenal Replacement Therapy.adverse effects.methodsen
dc.subject.otherRetrospective Studiesen
dc.titleCircuit lifespan during continuous renal replacement therapy for combined liver and kidney failure.en
dc.typeJournal Articleen
dc.identifier.journaltitleJournal of Critical Careen
dc.identifier.affiliationDepartment of Intensive Care, Austin Hospital, Melbourne, Australiaen
dc.identifier.doi10.1016/j.jcrc.2012.08.016en
dc.description.pages744.e7-15en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/23102533en
dc.type.austinJournal Articleen
local.name.researcherBaldwin, Ian C
item.openairetypeJournal Article-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.cerifentitytypePublications-
item.languageiso639-1en-
crisitem.author.deptIntensive Care-
crisitem.author.deptIntensive Care-
crisitem.author.deptData Analytics Research and Evaluation (DARE) Centre-
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