Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/11560
Full metadata record
DC FieldValueLanguage
dc.contributor.authorBellomo, Rinaldo-
dc.contributor.authorSuzuki, Satoshi-
dc.contributor.authorMarino, Bruno-
dc.contributor.authorStarkey, Graham-
dc.contributor.authorChambers, Brenton-
dc.contributor.authorFink, Michael A-
dc.contributor.authorWang, Bao Zhong-
dc.contributor.authorHouston, Shane-
dc.contributor.authorEastwood, Glenn M-
dc.contributor.authorCalzavacca, Paolo-
dc.contributor.authorGlassford, Neil J-
dc.contributor.authorSkene, Alison-
dc.contributor.authorJones, Daryl A-
dc.contributor.authorJones, Robert M-
dc.date.accessioned2015-05-16T01:10:27Z
dc.date.available2015-05-16T01:10:27Z
dc.date.issued2012-09-01-
dc.identifier.citationCritical Care and Resuscitation; 14(3): 173-6en_US
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/11560en
dc.description.abstractLiver transplantation is a major life-saving procedure, and donation after cardiac death (DCD) has increased the pool of potential liver donors. However, DCD livers are at increased risk of primary graft dysfunction and biliary tract ischaemia. Normothermic extracorporeal liver perfusion (NELP) may increase the ability to protect, evaluate and, in future, transplant DCD livers. We conducted proof-of-concept experiments using a DCD model in the pig to assess the short-term (4 hours) feasibility and functional efficacy of NELP. Using extracorporeal membrane oxygenation, parenteral nutrition, separate hepatic artery and portal vein perfusion, and physiological perfusion pressures, we achieved NELP and evidence of function (bile production, paracetamol removal, maintenance of normal ammonia and lactate levels) for 4 hours in pig livers subjected to 15 and 30 minutes of cardiac arrest before explantation. Our experiments justify further investigations of the feasibility and efficacy of human DCD liver preservation by ex-vivo perfusion.en_US
dc.language.isoenen
dc.subject.otherAcetaminophen.analysisen
dc.subject.otherAnimalsen
dc.subject.otherExtracorporeal Circulationen
dc.subject.otherLiver.pathologyen
dc.subject.otherLiver Circulationen
dc.subject.otherLiver Transplantationen
dc.subject.otherOrgan Preservation.methodsen
dc.subject.otherPerfusion.instrumentation.methodsen
dc.subject.otherSwineen
dc.subject.otherTemperatureen
dc.subject.otherWarm Ischemiaen
dc.titleNormothermic extracorporeal perfusion of isolated porcine liver after warm ischaemia: a preliminary report.en_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleCritical Care and Resuscitationen_US
dc.identifier.affiliationAustin Healthen_US
dc.description.pages173-6en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/22963210en
dc.type.contentTexten_US
dc.type.austinJournal Articleen
local.name.researcherBellomo, Rinaldo
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptIntensive Care-
crisitem.author.deptData Analytics Research and Evaluation (DARE) Centre-
crisitem.author.deptVictorian Liver Transplant Unit-
crisitem.author.deptSurgery-
crisitem.author.deptIntensive Care-
crisitem.author.deptPathology-
crisitem.author.deptIntensive Care-
crisitem.author.deptVictorian Liver Transplant Unit-
crisitem.author.deptSurgery (University of Melbourne)-
crisitem.author.deptHepatopancreatobiliary Surgery-
crisitem.author.deptGastroenterology and Hepatology-
Appears in Collections:Journal articles
Show simple item record

Page view(s)

52
checked on Mar 28, 2024

Google ScholarTM

Check


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.