Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/11534
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dc.contributor.authorMuralidharan, Vijayaragavanen
dc.contributor.authorKwok, Marcoen
dc.contributor.authorLee, Sze Tingen
dc.contributor.authorLau, Lawrence Fen
dc.contributor.authorScott, Andrew Men
dc.contributor.authorChristophi, Christopheren
dc.date.accessioned2015-05-16T01:08:53Z
dc.date.available2015-05-16T01:08:53Z
dc.date.issued2012-07-13en
dc.identifier.citationJournal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine 2012; 53(9): 1345-51en
dc.identifier.govdoc22797376en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/11534en
dc.description.abstractModern multidisciplinary therapy for colorectal liver metastases (CRLM) is associated with significant morbidity and must be adapted to the patient's relative risk. The tools currently available to risk-stratify patients are limited. This study assessed the prognostic utility of metabolic measurements derived from(18)F-FDG PET compared with previously proposed prognostic scoring systems.Preoperative (18)F-FDG PET/CT studies from a series of 30 patients who underwent liver resection for CRLM after neoadjuvant chemotherapy were evaluated. Quantitative (18)F-FDG PET analysis calculated the maximum and mean standardized uptake value, metabolic tumor volume (MTV), and tumor glycolytic volume (TGV) as measures of the metabolic activity of tumors. The predictive value of these parameters was compared with that of 4 prognostic scores developed by Fong, Iwatsuki, Nordlinger, and Rees.High MTV and TGV in patients before metastasectomy were significantly associated with poorer overall survival (MTV: P = 0.001; TGV: P = 0.004) and recurrence-free survival (MTV: P = 0.001, TGV; P = 0.002). Maximum and mean standardized uptake value did not show any significant predictive ability. Of the prognostic scores, prediction of outcome was most accurate using the Basingstoke index (area under the curve, 0.898).Assessment of metabolic tumor burden with volumetric (18)F-FDG PET parameters appears to be a valuable adjunct in determining the biology of CRLM before surgical resection and may enable better risk stratification of patients.en
dc.language.isoenen
dc.subject.otherAdulten
dc.subject.otherAgeden
dc.subject.otherAged, 80 and overen
dc.subject.otherBiological Transporten
dc.subject.otherColorectal Neoplasms.pathologyen
dc.subject.otherFluorodeoxyglucose F18.diagnostic useen
dc.subject.otherGlycolysisen
dc.subject.otherHumansen
dc.subject.otherLiver Neoplasms.metabolism.pathology.radionuclide imaging.secondaryen
dc.subject.otherMaleen
dc.subject.otherMiddle Ageden
dc.subject.otherMultimodal Imagingen
dc.subject.otherPositron-Emission Tomographyen
dc.subject.otherPrognosisen
dc.subject.otherROC Curveen
dc.subject.otherRetrospective Studiesen
dc.subject.otherSurvival Analysisen
dc.subject.otherTomography, X-Ray Computeden
dc.subject.otherTumor Burdenen
dc.titlePrognostic ability of 18F-FDG PET/CT in the assessment of colorectal liver metastases.en
dc.typeJournal Articleen
dc.identifier.journaltitleJournal of Nuclear Medicineen
dc.identifier.affiliationDepartment of Surgery, Austin Hospital, University of Melbourne, Victoria, Australiaen
dc.identifier.doi10.2967/jnumed.112.102749en
dc.description.pages1345-51en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/22797376en
dc.type.austinJournal Articleen
local.name.researcherChristophi, Christopher
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptSurgery (University of Melbourne)-
crisitem.author.deptHepatopancreatobiliary Surgery-
crisitem.author.deptSurgery-
crisitem.author.deptMolecular Imaging and Therapy-
crisitem.author.deptSurgery (University of Melbourne)-
crisitem.author.deptMolecular Imaging and Therapy-
crisitem.author.deptOlivia Newton-John Cancer Research Institute-
crisitem.author.deptSurgery-
crisitem.author.deptHepatopancreatobiliary Surgery-
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