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Title: The dorsal motor nucleus of the vagus and regulation of pancreatic secretory function.
Authors: Mussa, Bashair M;Verberne, Anthony J M
Affiliation: University of Melbourne, Department of Medicine, Clinical Pharmacology & Therapeutics Unit, Austin Health, Heidelberg, Victoria 3084 Australia
Issue Date: 1-Jun-2012
Citation: Experimental Physiology 2012; 98(1): 25-37
Abstract: Recent investigation of the factors and pathways that are involved in regulation of pancreatic secretory function (PSF) has led to development of a pancreatic vagovagal reflex model. This model consists of three elements, including pancreatic vagal afferents, the dorsal motor nucleus of the vagus (DMV) and pancreatic vagal efferents. The DMV has been recognized as a major component of this model and so this review focuses on the role of this nucleus in regulation of PSF. Classically, the control of the PSF has been viewed as being dependent on gastrointestinal hormones and vagovagal reflex pathways. However, recent studies have suggested that these two mechanisms act synergistically to mediate pancreatic secretion. The DMV is the major source of vagal motor output to the pancreas, and this output is modulated by various neurotransmitters and synaptic inputs from other central autonomic regulatory circuits, including the nucleus of the solitary tract. Endogenously occurring excitatory (glutamate) and inhibitory amino acids (GABA) have a marked influence on DMV vagal output to the pancreas. In addition, a variety of neurotransmitters and receptors for gastrointestinal peptides and hormones have been localized in the DMV, emphasizing the direct and indirect involvement of this nucleus in control of PSF.
Internal ID Number: 22660814
DOI: 10.1113/expphysiol.2012.066472
Type: Journal Article
Subjects: Afferent Pathways.physiology
Efferent Pathways.physiology
Glucagon-Like Peptide 1.secretion
Motor Neurons.physiology
Nitric Oxide.physiology
Pancreatic Polypeptide.secretion
Parasympathetic Nervous System.physiology
Thyrotropin-Releasing Hormone.secretion
Vagus Nerve.physiology
Appears in Collections:Journal articles

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