Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/11424
Title: Temperature dependence of angiotensin II-mediated depolarisation of the rat isolated nodose ganglion.
Authors: Widdop, Robert E;Krstew, E;Jarrott, B
Affiliation: University of Melbourne, Department of Medicine, Austin Hospital, Heidelberg, Victoria, Australia.
Issue Date: 21-Aug-1990
Citation: European Journal of Pharmacology; 185(1): 107-11
Abstract: The ability of angiotensin II (A II) and 5-hydroxytryptamine (5-HT) to depolarise the rat isolated nodose ganglion preparation was examined. 5-HT depolarised the nodose ganglion, both at room temperature (20-24 degrees C) and at 35-37 degrees C. However, A II depolarised the nodose ganglion only under the latter condition, and these responses were blocked by the A II receptor antagonist saralasin. This study extends previous findings which have demonstrated A II binding sites on the nodose ganglion and axon, and identifies the rat nodose ganglion as a sensitive preparation in which to study the interactions between neuronal A II receptor activation and its blockade by A II receptor antagonists.
Internal ID Number: 2226630
URI: http://ahro.austin.org.au/austinjspui/handle/1/11424
URL: http://www.ncbi.nlm.nih.gov/pubmed/2226630
Type: Journal Article
Subjects: Angiotensin II.physiology
Animals
Dose-Response Relationship, Drug
Male
Neuromuscular Depolarizing Agents
Nodose Ganglion.drug effects.physiology
Rats
Rats, Inbred Strains
Saralasin.pharmacology
Serotonin.pharmacology
Temperature
Appears in Collections:Journal articles

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