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|Title:||Temperature dependence of angiotensin II-mediated depolarisation of the rat isolated nodose ganglion.|
|Authors:||Widdop, Robert E;Krstew, E;Jarrott, B|
|Affiliation:||University of Melbourne, Department of Medicine, Austin Hospital, Heidelberg, Victoria, Australia.|
|Citation:||European Journal of Pharmacology; 185(1): 107-11|
|Abstract:||The ability of angiotensin II (A II) and 5-hydroxytryptamine (5-HT) to depolarise the rat isolated nodose ganglion preparation was examined. 5-HT depolarised the nodose ganglion, both at room temperature (20-24 degrees C) and at 35-37 degrees C. However, A II depolarised the nodose ganglion only under the latter condition, and these responses were blocked by the A II receptor antagonist saralasin. This study extends previous findings which have demonstrated A II binding sites on the nodose ganglion and axon, and identifies the rat nodose ganglion as a sensitive preparation in which to study the interactions between neuronal A II receptor activation and its blockade by A II receptor antagonists.|
|Internal ID Number:||2226630|
Dose-Response Relationship, Drug
Neuromuscular Depolarizing Agents
Nodose Ganglion.drug effects.physiology
Rats, Inbred Strains
|Appears in Collections:||Journal articles|
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