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|Title:||A novel method for detecting antigen-specific human regulatory T cells.|
|Authors:||Ebert, Lisa M;MacRaild, Sarah E;Davis, Ian D;Cebon, Jonathan S;Chen, Weisan|
|Affiliation:||Ludwig Institute for Cancer Research (Melbourne-Austin Branch), Melbourne, Australia|
|Citation:||Journal of Immunological Methods 2012; 377(1-2): 56-61|
|Abstract:||Antigenic epitopes recognized by FoxP3(+) regulatory T cells (Treg) are poorly defined, largely due to a lack of assays for determining Treg specificity. We have developed a novel approach for detecting human Treg specific to peptide antigen, utilizing down-regulation of surface CD3 as a read-out of antigen recognition. Culture conditions and re-stimulation time have been optimized, allowing the detection of even very rare Treg, such as those specific to tumor antigens.|
|Internal ID Number:||22265970|
Forkhead Transcription Factors.immunology
|Appears in Collections:||Journal articles|
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