Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/11420
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dc.contributor.authorAtan, Rafidahen
dc.contributor.authorCrosbie, Daviden
dc.contributor.authorBellomo, Rinaldoen
dc.date.accessioned2015-05-16T01:01:34Z
dc.date.available2015-05-16T01:01:34Z
dc.date.issued2012-01-13en
dc.identifier.citationBlood Purification 2012; 33(1-3): 88-100en
dc.identifier.govdoc22248671en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/11420en
dc.description.abstractAttempts at achieving cytokine homeostasis include blood purification to deliver cytokine removal. Assessment of ex vivo studies for optimal operating conditions is a vital step.We conducted a systematic search for ex vivo studies on cytokine removal using known modalities of extracorporeal circulation. We selected 29 articles and analyzed data according to clearance, sieving coefficient, ultrafiltrate concentration and percentage removal.We identified four main techniques for cytokine removal: standard techniques, high cut-off (HCO) techniques, adsorption techniques and combined plasma filtration adsorption. HCO hemofiltration (HCO/HF) showed greatest consistency in cytokine removal among all approaches. Mean albumin clearance with HCO filters was 3.74 ml/min.Ex vivo data support the view that HCO/HF is the most consistently effective approach in terms of sieving and clearance. Further investigation of HCO/HF in randomized controlled trials in animal models and humans seems desirable.en
dc.language.isoenen
dc.subject.otherAdsorptionen
dc.subject.otherAnimalsen
dc.subject.otherCytokines.blood.isolation & purificationen
dc.subject.otherHemofiltration.instrumentation.methodsen
dc.subject.otherHumansen
dc.subject.otherPlasma Exchange.instrumentation.methodsen
dc.subject.otherPlasmapheresis.instrumentation.methodsen
dc.subject.otherRenal Replacement Therapy.instrumentation.methodsen
dc.titleTechniques of extracorporeal cytokine removal: a systematic review of the literature.en
dc.typeJournal Articleen
dc.identifier.journaltitleBlood purificationen
dc.identifier.affiliationDepartment of Intensive Care, Austin Hospital, Heidelberg, Vic., Australia.en
dc.identifier.doi10.1159/000333845en
dc.description.pages88-100en
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pubmed/22248671en
Appears in Collections:Journal articles

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