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Title: Comparison of immunoglobulin G subclass concentrations in severe community-acquired pneumonia and severe pandemic 2009 influenza A (H1N1) infection.
Authors: Gordon, Claire L;Holmes, Natasha E;Grayson, M Lindsay;Torresi, Joseph;Johnson, Paul D R;Cheng, Allen C;Charles, Patrick G P
Affiliation: Department of Infectious Diseases, Austin Health, Melbourne, Australia
Issue Date: 11-Jan-2012
Citation: Clinical and Vaccine Immunology : Cvi 2012; 19(3): 446-8
Abstract: We compared immunoglobulin G (IgG) subclasses in patients with severe noninfluenza community-acquired pneumonia (CAP) to those in patients with severe pandemic 2009 influenza (H1N1) virus infection. Low IgG1 and IgG2 levels occurred often in the CAP group; however, H1N1 patients had lower IgG1 and IgG2 levels (5.4 versus 3.3 g/liter [P = 0.008] and 2.5 versus 1.2 g/liter [P < 0.001], respectively). Low IgG2 levels may be specifically linked to severe H1N1; however, it is not clear whether this association is related to H1N1 or to other features of severity.
Internal ID Number: 22237894
DOI: 10.1128/CVI.05518-11
Type: Journal Article
Subjects: Adolescent
Community-Acquired Infections.immunology
Immunoglobulin G.blood.classification
Influenza A Virus, H1N1 Subtype.isolation & purification
Influenza, Human.immunology.virology
Middle Aged
Pneumonia, Bacterial.immunology
Young Adult
Appears in Collections:Journal articles

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